Monoclonal Antibody Targeting of Fibroblast Growth Factor Receptor 1c Ameliorates Obesity and Glucose Intolerance via Central Mechanisms

Christopher J. Lelliott; Andrea Ahnmark; Therese Admyre; Ingela Ahlstedt; Lorraine Irving; Feenagh Keyes; Laurel Patterson; Michael B. Mumphrey; Mikael Bjursell; Tracy Gorman; Mohammad Bohlooly-Y; Andrew Buchanan; Paula Harrison; Tristan Vaughan; Hans-Rudolf Berthoud; Daniel Lindén

doi:10.1371/journal.pone.0112109

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Peer-reviewed

Research Article

Monoclonal Antibody Targeting of Fibroblast Growth Factor Receptor 1c Ameliorates Obesity and Glucose Intolerance via Central Mechanisms

Christopher J. Lelliott,

Current address: Wellcome Trust Sanger Institute, Hinxton, United Kingdom

Affiliation Cardiovascular & Metabolic Disease Innovative Medicines, Dept of Bioscience Diabetes, AstraZeneca, Mölndal, Sweden
⨯
Andrea Ahnmark,

Affiliation Cardiovascular & Metabolic Disease Innovative Medicines, Dept of Bioscience Diabetes, AstraZeneca, Mölndal, Sweden
⨯
Therese Admyre,

Affiliation Discovery Sciences Transgenics, AstraZeneca, Mölndal, Sweden
⨯
Ingela Ahlstedt,

Affiliation Cardiovascular & Metabolic Disease Innovative Medicines, Dept of Bioscience Diabetes, AstraZeneca, Mölndal, Sweden
⨯
Lorraine Irving,

Affiliation Antibody Discovery and Protein Engineering, MedImmune, Cambridge, United Kingdom
⨯
Feenagh Keyes,

Affiliation Antibody Discovery and Protein Engineering, MedImmune, Cambridge, United Kingdom
⨯
Laurel Patterson,

Affiliation Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Baton Rouge, United States of America
⨯
Michael B. Mumphrey,

Affiliation Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Baton Rouge, United States of America
⨯
Mikael Bjursell,

Affiliation Discovery Sciences Transgenics, AstraZeneca, Mölndal, Sweden
⨯
Tracy Gorman,

Affiliation AstraZeneca, Discovery Sciences, Mereside, Alderley Park, Macclesfield, Cheshire, United Kingdom
⨯
Mohammad Bohlooly-Y,

Affiliation Discovery Sciences Transgenics, AstraZeneca, Mölndal, Sweden
⨯
Andrew Buchanan,

Affiliation Antibody Discovery and Protein Engineering, MedImmune, Cambridge, United Kingdom
⨯
Paula Harrison ,

¶† Deceased.

Affiliation Antibody Discovery and Protein Engineering, MedImmune, Cambridge, United Kingdom
⨯
Tristan Vaughan,

Affiliation Antibody Discovery and Protein Engineering, MedImmune, Cambridge, United Kingdom
⨯
Hans-Rudolf Berthoud,

Affiliation Neurobiology of Nutrition Laboratory, Pennington Biomedical Research Center, Baton Rouge, United States of America
⨯
[ ... ],
Daniel Lindén

* E-mail: daniel.linden@astrazeneca.com

Affiliation Cardiovascular & Metabolic Disease Innovative Medicines, Dept of Bioscience Diabetes, AstraZeneca, Mölndal, Sweden
⨯
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Monoclonal Antibody Targeting of Fibroblast Growth Factor Receptor 1c Ameliorates Obesity and Glucose Intolerance via Central Mechanisms

Christopher J. Lelliott,
Andrea Ahnmark,
Therese Admyre,
Ingela Ahlstedt,
Lorraine Irving,
Feenagh Keyes,
Laurel Patterson,
Michael B. Mumphrey,
Mikael Bjursell,
Tracy Gorman

Published: November 26, 2014
https://doi.org/10.1371/journal.pone.0112109

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