Aging Increases the Susceptivity of MSCs to Reactive Oxygen Species and Impairs Their Therapeutic Potency for Myocardial Infarction

Liang Li; Yingfei Guo; Hongxia Zhai; Yaxin Yin; Jinjin Zhang; Haiwei Chen; Lei Wang; Na Li; Runmei Liu; Yunfeng Xia

doi:10.1371/journal.pone.0111850

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Open Access

Peer-reviewed

Research Article

Aging Increases the Susceptivity of MSCs to Reactive Oxygen Species and Impairs Their Therapeutic Potency for Myocardial Infarction

Liang Li ,

Contributed equally to this work with: Liang Li, Yingfei Guo

Affiliation First Department of Cadres, First Hospital Affiliated to General Hospital of People's Liberation Army, Beijing, China
⨯
Yingfei Guo ,

Contributed equally to this work with: Liang Li, Yingfei Guo

Affiliation Department of Emergency, First hospital affiliated to general hospital of People's Liberation Army, Beijing, China
⨯
Hongxia Zhai,

Affiliation First Department of Cadres, First Hospital Affiliated to General Hospital of People's Liberation Army, Beijing, China
⨯
Yaxin Yin,

Affiliation First Department of Cadres, First Hospital Affiliated to General Hospital of People's Liberation Army, Beijing, China
⨯
Jinjin Zhang,

Affiliation First Department of Cadres, First Hospital Affiliated to General Hospital of People's Liberation Army, Beijing, China
⨯
Haiwei Chen,

Affiliation First Department of Cadres, First Hospital Affiliated to General Hospital of People's Liberation Army, Beijing, China
⨯
Lei Wang,

Affiliation First Department of Cadres, First Hospital Affiliated to General Hospital of People's Liberation Army, Beijing, China
⨯
Na Li,

Affiliation First Department of Cadres, First Hospital Affiliated to General Hospital of People's Liberation Army, Beijing, China
⨯
Runmei Liu,

Affiliation First Department of Cadres, First Hospital Affiliated to General Hospital of People's Liberation Army, Beijing, China
⨯
Yunfeng Xia

* E-mail: xiayf3691@sina.com

Affiliation First Department of Cadres, First Hospital Affiliated to General Hospital of People's Liberation Army, Beijing, China
⨯

Aging Increases the Susceptivity of MSCs to Reactive Oxygen Species and Impairs Their Therapeutic Potency for Myocardial Infarction

Liang Li,
Yingfei Guo,
Hongxia Zhai,
Yaxin Yin,
Jinjin Zhang,
Haiwei Chen,
Lei Wang,
Na Li,
Runmei Liu,
Yunfeng Xia

Published: November 13, 2014
https://doi.org/10.1371/journal.pone.0111850

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Mesenchymal stem cells
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