Fibroblast Growth Factor 21 Improves Insulin Sensitivity and Synergizes with Insulin in Human Adipose Stem Cell-Derived (hASC) Adipocytes

Darwin V. Lee; Dongmei Li; Qingyun Yan; Yimin Zhu; Bryan Goodwin; Roberto Calle; Martin B. Brenner; Saswata Talukdar

doi:10.1371/journal.pone.0111767

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Peer-reviewed

Research Article

Fibroblast Growth Factor 21 Improves Insulin Sensitivity and Synergizes with Insulin in Human Adipose Stem Cell-Derived (hASC) Adipocytes

Darwin V. Lee,

Affiliation Cardiovascular Metabolic and Endocrine Diseases (CVMED) Research Unit, Pfizer Worldwide Research & Development, Cambridge, MA, United States of America
⨯
Dongmei Li,

Affiliation Cardiovascular Metabolic and Endocrine Diseases (CVMED) Research Unit, Pfizer Worldwide Research & Development, Cambridge, MA, United States of America
⨯
Qingyun Yan,

Affiliation Cardiovascular Metabolic and Endocrine Diseases (CVMED) Research Unit, Pfizer Worldwide Research & Development, Cambridge, MA, United States of America
⨯
Yimin Zhu,

Affiliation Cardiovascular Metabolic and Endocrine Diseases (CVMED) Research Unit, Pfizer Worldwide Research & Development, Cambridge, MA, United States of America
⨯
Bryan Goodwin,

Affiliation Cardiovascular Metabolic and Endocrine Diseases (CVMED) Research Unit, Pfizer Worldwide Research & Development, Cambridge, MA, United States of America
⨯
Roberto Calle,

Affiliation Cardiovascular Metabolic and Endocrine Diseases (CVMED) Research Unit, Pfizer Worldwide Research & Development, Cambridge, MA, United States of America
⨯
Martin B. Brenner,

Current address: Merck Research Laboratories, Boston, MA, United States of America

Affiliation Cardiovascular Metabolic and Endocrine Diseases (CVMED) Research Unit, Pfizer Worldwide Research & Development, Cambridge, MA, United States of America
⨯
Saswata Talukdar

* E-mail: Saswata.Talukdar@pfizer.com

Affiliation Cardiovascular Metabolic and Endocrine Diseases (CVMED) Research Unit, Pfizer Worldwide Research & Development, Cambridge, MA, United States of America
⨯

Fibroblast Growth Factor 21 Improves Insulin Sensitivity and Synergizes with Insulin in Human Adipose Stem Cell-Derived (hASC) Adipocytes

Darwin V. Lee,
Dongmei Li,
Qingyun Yan,
Yimin Zhu,
Bryan Goodwin,
Roberto Calle,
Martin B. Brenner,
Saswata Talukdar

Published: November 3, 2014
https://doi.org/10.1371/journal.pone.0111767

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Insulin
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Fibroblast growth factor
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Glucose
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Adipocytes
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Adipose tissue
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Insulin signaling
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