Combining Use of Captopril and Losartan Attenuates the Progress of Streptococcus pneumoniae-Induced Tympanosclerosis through the Suppression of TGF-β1 Expression

Wenqing Yan; Jianfeng Li; Renjie Chai; Wentao Guo; Lei Xu; Yuechen Han; Xiaohui Bai; Haibo Wang

doi:10.1371/journal.pone.0111620

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Peer-reviewed

Research Article

Combining Use of Captopril and Losartan Attenuates the Progress of Streptococcus pneumoniae-Induced Tympanosclerosis through the Suppression of TGF-β1 Expression

Wenqing Yan,

Affiliations Department of Otolaryngology Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, P.R. China, Shandong Institute of Otolaryngology, Jinan, P.R. China
⨯
Jianfeng Li,

Affiliations Department of Otolaryngology Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, P.R. China, Shandong Institute of Otolaryngology, Jinan, P.R. China, Shandong Provincial Key Laboratory of Otology, Jinan, P.R. China
⨯
Renjie Chai,

Affiliation Key Laboratory for Developmental Genes and Human Disease, Ministry of Education, Institute of Life Sciences, Southeast University, Nanjing, P.R. China
⨯
Wentao Guo,

Affiliation Department of Otolaryngology Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, P.R. China
⨯
Lei Xu,

Affiliation Department of Otolaryngology Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, P.R. China
⨯
Yuechen Han,

Affiliation Department of Otolaryngology Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, P.R. China
⨯
Xiaohui Bai ,

* E-mail: sphbaixiaohui@hotmail.com (XB); wang.hb7585@hotmail.com (HW)

Affiliations Department of Otolaryngology Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, P.R. China, Shandong Institute of Otolaryngology, Jinan, P.R. China, Shandong Provincial Key Laboratory of Otology, Jinan, P.R. China
⨯
Haibo Wang

* E-mail: sphbaixiaohui@hotmail.com (XB); wang.hb7585@hotmail.com (HW)

Affiliations Department of Otolaryngology Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan, P.R. China, Shandong Institute of Otolaryngology, Jinan, P.R. China, Shandong Provincial Key Laboratory of Otology, Jinan, P.R. China
⨯

Combining Use of Captopril and Losartan Attenuates the Progress of Streptococcus pneumoniae-Induced Tympanosclerosis through the Suppression of TGF-β1 Expression

Wenqing Yan,
Jianfeng Li,
Renjie Chai,
Wentao Guo,
Lei Xu,
Yuechen Han,
Xiaohui Bai,
Haibo Wang

Published: October 31, 2014
https://doi.org/10.1371/journal.pone.0111620

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