The Effect of 3D Nanofibrous Scaffolds on the Chondrogenesis of Induced Pluripotent Stem Cells and Their Application in Restoration of Cartilage Defects

Ji Liu; Huarong Nie; Zhengliang Xu; Xin Niu; Shangchun Guo; Junhui Yin; Fei Guo; Gang Li; Yang Wang; Changqing Zhang

doi:10.1371/journal.pone.0111566

Loading metrics

Open Access

Peer-reviewed

Research Article

The Effect of 3D Nanofibrous Scaffolds on the Chondrogenesis of Induced Pluripotent Stem Cells and Their Application in Restoration of Cartilage Defects

Ji Liu,

Affiliation Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
⨯
Huarong Nie,

Affiliation Institute of Polymers, School of Materials Science and Engineering, Nanchang University, Nanchang, China
⨯
Zhengliang Xu,

Affiliation Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
⨯
Xin Niu,

Affiliation Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
⨯
Shangchun Guo,

Affiliation Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
⨯
Junhui Yin,

Affiliation Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
⨯
Fei Guo,

Affiliation Institute of Polymers, School of Materials Science and Engineering, Nanchang University, Nanchang, China
⨯
Gang Li,

Affiliation Department of Orthopaedics & Traumatology, Stem Cells and Regeneration Program, School of Biomedical Sciences, Room 904, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong, SAR, PR China
⨯
Yang Wang ,

* E-mail: zhangcq@sjtu.edu.cn (CZ); wangy63cn@126.com (YW)

Affiliation Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
⨯
Changqing Zhang

* E-mail: zhangcq@sjtu.edu.cn (CZ); wangy63cn@126.com (YW)

Affiliation Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
⨯

The Effect of 3D Nanofibrous Scaffolds on the Chondrogenesis of Induced Pluripotent Stem Cells and Their Application in Restoration of Cartilage Defects

Ji Liu,
Huarong Nie,
Zhengliang Xu,
Xin Niu,
Shangchun Guo,
Junhui Yin,
Fei Guo,
Gang Li,
Yang Wang,
Changqing Zhang

Published: November 12, 2014
https://doi.org/10.1371/journal.pone.0111566

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cartilage
Is the Subject Area "Cartilage" applicable to this article?

Thanks for your feedback.
Collagens
Is the Subject Area "Collagens" applicable to this article?

Thanks for your feedback.
Induced pluripotent stem cells
Is the Subject Area "Induced pluripotent stem cells" applicable to this article?

Thanks for your feedback.
Regeneration
Is the Subject Area "Regeneration" applicable to this article?

Thanks for your feedback.
Gelatin
Is the Subject Area "Gelatin" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Articular cartilage
Is the Subject Area "Articular cartilage" applicable to this article?

Thanks for your feedback.
Cell differentiation
Is the Subject Area "Cell differentiation" applicable to this article?

Thanks for your feedback.