Mutations at Beta N265 in γ-Aminobutyric Acid Type A Receptors Alter Both Binding Affinity and Efficacy of Potent Anesthetics

• Deirdre S. Stewart,

  Affiliation Department of Anesthesia Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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• David W. Pierce,

  Affiliation Department of Anesthesia Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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• Mayo Hotta,

  Current address: Keck School of Medicine of the University of Southern California, Los Angeles, California, United States of Amerca

  Affiliation Department of Anesthesia Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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• Alex T. Stern,

  Affiliation Department of Anesthesia Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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• Stuart A. Forman

  * E-mail: saforman@partners.org

  Affiliation Department of Anesthesia Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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