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Open Access

Peer-reviewed

Research Article

P2Y₆ Receptor Potentiates Pro-Inflammatory Responses in Macrophages and Exhibits Differential Roles in Atherosclerotic Lesion Development

Ricardo A. Garcia,

Affiliation Cardiovascular Drug Discovery, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
⨯
Mujing Yan,

Affiliation Cardiovascular Drug Discovery, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
⨯
Debra Search,

Affiliation Cardiovascular Drug Discovery, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
⨯
Rongan Zhang,

Affiliation Cardiovascular Drug Discovery, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
⨯
Nancy L. Carson,

Affiliation Cardiovascular Drug Discovery, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
⨯
Carol S. Ryan,

Affiliation Cardiovascular Drug Discovery, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
⨯
Constance Smith-Monroy,

Affiliation Applied Genomics, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
⨯
Joanna Zheng,

Affiliation Pharmaceutical Compound Optimization: Discovery Toxicology, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
⨯
Jian Chen,

Affiliation Applied Genomics, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
⨯
Yan Kong,

Affiliation Lead Evaluation, Bristol-Myers Squibb Company, Lawrenceville, New Jersey, United States of America
⨯
Huaping Tang,

Affiliation Lead Evaluation, Bristol-Myers Squibb Company, Lawrenceville, New Jersey, United States of America
⨯
Samuel E. Hellings,

Affiliation Cardiovascular Drug Discovery, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
⨯
Judith Wardwell-Swanson,

Affiliation Applied Genomics, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
⨯
Joseph E. Dinchuk,

Affiliation Applied Genomics, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
⨯
George C. Psaltis,

Affiliation Veterinary Sciences, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
⨯
David A. Gordon,

Affiliation Cardiovascular Drug Discovery, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
⨯
Peter W. Glunz,

Affiliation Discovery Chemistry, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
⨯
[ ... ],
Peter S. Gargalovic

* E-mail: peter.gargalovic@bms.com

Affiliation Cardiovascular Drug Discovery, Bristol-Myers Squibb Company, Pennington, New Jersey, United States of America
⨯
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P2Y₆ Receptor Potentiates Pro-Inflammatory Responses in Macrophages and Exhibits Differential Roles in Atherosclerotic Lesion Development

Ricardo A. Garcia,
Mujing Yan,
Debra Search,
Rongan Zhang,
Nancy L. Carson,
Carol S. Ryan,
Constance Smith-Monroy,
Joanna Zheng,
Jian Chen,
Yan Kong

x

Published: October 31, 2014
https://doi.org/10.1371/journal.pone.0111385

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Macrophages
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Atherosclerosis
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Cytokines
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Inflammation
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Aneurysms
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Aorta
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Mouse models
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