ASPP2 Links the Apical Lateral Polarity Complex to the Regulation of YAP Activity in Epithelial Cells

Christophe Royer; Sofia Koch; Xiao Qin; Jaroslav Zak; Ludovico Buti; Ewa Dudziec; Shan Zhong; Indrika Ratnayaka; Shankar Srinivas; Xin Lu

doi:10.1371/journal.pone.0111384

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Open Access

Peer-reviewed

Research Article

ASPP2 Links the Apical Lateral Polarity Complex to the Regulation of YAP Activity in Epithelial Cells

Christophe Royer ,

* E-mail: royer@dpag.ox.ac.uk (CR); xin.lu@ludwig.ox.ac.uk (XL)

Affiliations Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
⨯
Sofia Koch,

Affiliation Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
⨯
Xiao Qin,

Affiliation Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
⨯
Jaroslav Zak,

Affiliation Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
⨯
Ludovico Buti,

Affiliation Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
⨯
Ewa Dudziec,

Affiliation Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
⨯
Shan Zhong,

Affiliation Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
⨯
Indrika Ratnayaka,

Affiliation Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
⨯
Shankar Srinivas,

Affiliation Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom
⨯
Xin Lu

* E-mail: royer@dpag.ox.ac.uk (CR); xin.lu@ludwig.ox.ac.uk (XL)

Affiliation Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom
⨯

ASPP2 Links the Apical Lateral Polarity Complex to the Regulation of YAP Activity in Epithelial Cells

Christophe Royer,
Sofia Koch,
Xiao Qin,
Jaroslav Zak,
Ludovico Buti,
Ewa Dudziec,
Shan Zhong,
Indrika Ratnayaka,
Shankar Srinivas,
Xin Lu

Published: October 31, 2014
https://doi.org/10.1371/journal.pone.0111384

Reader Comments (2)

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02 Nov 2014
18:43 GMT
Most Recent

why YAP remains in the nuclear at high density Posted by tyrent001 on 02 Nov 2014 at 18:43 GMT
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02 Nov 2014
17:59 GMT
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HOW TO EXPLAIN THE PARADOX? Posted by tyrent001 on 02 Nov 2014 at 17:59 GMT

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Phosphorylation
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Caco-2 cells
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Cell polarity
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Colon
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Epithelial cells
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Tight junctions
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Immunoprecipitation
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