Lack of Negatively Charged Residues at the External Mouth of Kir2.2 Channels Enable the Voltage-Dependent Block by External Mg²⁺

• Junwei Li,

  Affiliation Institute of Biophysics, Hebei University of Technology, Tianjin, China

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• Xiaoxiao Xie,

  Affiliation Institute of Biophysics, Hebei University of Technology, Tianjin, China

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• Jun Liu,

  Affiliation Institute of Biophysics, Hebei University of Technology, Tianjin, China

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• Hui Yu,

  Affiliation Institute of Biophysics, Hebei University of Technology, Tianjin, China

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• Suhua Zhang,

  Affiliation Institute of Biophysics, Hebei University of Technology, Tianjin, China

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• Yong Zhan ,

  * E-mail: hailong_an@hebut.edu.cn (HA); zhany@hebut.edu.cn (YZ)

  Affiliation Institute of Biophysics, Hebei University of Technology, Tianjin, China

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• Hailin Zhang,

  Affiliation Key Laboratory of Neural and Vascular Biology, Ministry of Education, Key Laboratory of Pharmacology and Toxicology for New Drug, Hebei Province, Department of Pharmacology, Hebei Medical University, Shijiazhuang, Hebei Province, China

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• Diomedes E. Logothetis,

  Affiliation Department of Physiology and Biophysics, School of Medicine, Virginia Commonwealth University, Richmond, VA, United States of America

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• Hailong An

  * E-mail: hailong_an@hebut.edu.cn (HA); zhany@hebut.edu.cn (YZ)

  Affiliation Institute of Biophysics, Hebei University of Technology, Tianjin, China

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