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Open Access

Peer-reviewed

Research Article

Sustained Radiosensitization of Hypoxic Glioma Cells after Oxygen Pretreatment in an Animal Model of Glioblastoma and In Vitro Models of Tumor Hypoxia

Ryon H. Clarke,

Affiliations Department of Neuroscience, University of Virginia, Charlottesville, VA, United States of America, School of Medicine, University of Virginia Health System, Charlottesville, VA, United States of America
⨯
Shayan Moosa,

Affiliation School of Medicine, University of Virginia Health System, Charlottesville, VA, United States of America
⨯
Matthew Anzivino,

Affiliations Department of Neuroscience, University of Virginia, Charlottesville, VA, United States of America, School of Medicine, University of Virginia Health System, Charlottesville, VA, United States of America
⨯
Yi Wang,

Affiliations Department of Neuroscience, University of Virginia, Charlottesville, VA, United States of America, School of Medicine, University of Virginia Health System, Charlottesville, VA, United States of America
⨯
Desiree Hunt Floyd,

Affiliations School of Medicine, University of Virginia Health System, Charlottesville, VA, United States of America, Division of Neuro-Oncology, Departments of Neurology, Microbiology, and Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, VA, United States of America
⨯
Benjamin W. Purow,

Affiliations School of Medicine, University of Virginia Health System, Charlottesville, VA, United States of America, Division of Neuro-Oncology, Departments of Neurology, Microbiology, and Biochemistry and Molecular Genetics, University of Virginia Health System, Charlottesville, VA, United States of America
⨯
Kevin S. Lee

* E-mail: ksl3h@virginia.edu

Affiliations Department of Neuroscience, University of Virginia, Charlottesville, VA, United States of America, School of Medicine, University of Virginia Health System, Charlottesville, VA, United States of America, Department of Neurological Surgery, University of Virginia, Charlottesville, VA, United States of America
⨯

Sustained Radiosensitization of Hypoxic Glioma Cells after Oxygen Pretreatment in an Animal Model of Glioblastoma and In Vitro Models of Tumor Hypoxia

Ryon H. Clarke,
Shayan Moosa,
Matthew Anzivino,
Yi Wang,
Desiree Hunt Floyd,
Benjamin W. Purow,
Kevin S. Lee

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Published: October 28, 2014
https://doi.org/10.1371/journal.pone.0111199

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Radiation therapy
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Hypoxia
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Oxygen
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Cancers and neoplasms
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Glioma cells
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Cancer treatment
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Malignant tumors
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Medical hypoxia
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