Heat Stress Induces Apoptosis through a Ca2+-Mediated Mitochondrial Apoptotic Pathway in Human Umbilical Vein Endothelial Cells

Li Li; Hongping Tan; Zhengtao Gu; Zhifeng Liu; Yan Geng; Yunsong Liu; Huasheng Tong; Youqing Tang; Junmin Qiu; Lei Su

doi:10.1371/journal.pone.0111083

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Open Access

Peer-reviewed

Research Article

Heat Stress Induces Apoptosis through a Ca²⁺-Mediated Mitochondrial Apoptotic Pathway in Human Umbilical Vein Endothelial Cells

Li Li ,

Contributed equally to this work with: Li Li, Hongping Tan, Zhengtao Gu

Affiliation Department of intensive care unit, Guangzhou General Hospital of Guangzhou Military Command, Key Laboratory of Tropical Zone Trauma Care and Tissue Repair of PLA, Guangzhou, P.R. China, and Southern Medical University, Guangzhou, P.R. China
⨯
Hongping Tan ,

Contributed equally to this work with: Li Li, Hongping Tan, Zhengtao Gu

Affiliation Department of epilepsy surgery, Guangdong Sanjiu Brain Hospital, Guangzhou, P.R. China
⨯
Zhengtao Gu ,

Contributed equally to this work with: Li Li, Hongping Tan, Zhengtao Gu

Affiliation Department of intensive care unit, The Third Affiliated Hospital of Southern Medical University, Guangzhou, P.R. China
⨯
Zhifeng Liu,

Affiliation Department of intensive care unit, Guangzhou General Hospital of Guangzhou Military Command, Key Laboratory of Tropical Zone Trauma Care and Tissue Repair of PLA, Guangzhou, P.R. China
⨯
Yan Geng,

Affiliation Department of intensive care unit, Guangzhou General Hospital of Guangzhou Military Command, Key Laboratory of Tropical Zone Trauma Care and Tissue Repair of PLA, Guangzhou, P.R. China
⨯
Yunsong Liu,

Affiliation Department of intensive care unit, Guangzhou General Hospital of Guangzhou Military Command, Key Laboratory of Tropical Zone Trauma Care and Tissue Repair of PLA, Guangzhou, P.R. China
⨯
Huasheng Tong,

Affiliation Department of intensive care unit, Guangzhou General Hospital of Guangzhou Military Command, Key Laboratory of Tropical Zone Trauma Care and Tissue Repair of PLA, Guangzhou, P.R. China
⨯
Youqing Tang,

Affiliation Department of intensive care unit, Guangzhou General Hospital of Guangzhou Military Command, Key Laboratory of Tropical Zone Trauma Care and Tissue Repair of PLA, Guangzhou, P.R. China
⨯
Junmin Qiu,

Affiliation Department of intensive care unit, Guangzhou General Hospital of Guangzhou Military Command, Key Laboratory of Tropical Zone Trauma Care and Tissue Repair of PLA, Guangzhou, P.R. China
⨯
Lei Su

* E-mail: sulei_ICU@163.com

Affiliation Department of intensive care unit, Guangzhou General Hospital of Guangzhou Military Command, Key Laboratory of Tropical Zone Trauma Care and Tissue Repair of PLA, Guangzhou, P.R. China
⨯

Heat Stress Induces Apoptosis through a Ca²⁺-Mediated Mitochondrial Apoptotic Pathway in Human Umbilical Vein Endothelial Cells

Li Li,
Hongping Tan,
Zhengtao Gu,
Zhifeng Liu,
Yan Geng,
Yunsong Liu,
Huasheng Tong,
Youqing Tang,
Junmin Qiu,
Lei Su

Published: December 30, 2014
https://doi.org/10.1371/journal.pone.0111083

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Thermal stresses
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Apoptosis
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Endoplasmic reticulum
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Endothelial cells
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