Systemically Administered IgG Anti-Toxin Antibodies Protect the Colonic Mucosa during Infection with Clostridium difficile in the Piglet Model

Ocean R. Cohen; Jennifer A. Steele; Quanshun Zhang; Diane J. Schmidt; Yuankai Wang; Philip E. S. Hamel; Gillian Beamer; Bingling Xu; Saul Tzipori

doi:10.1371/journal.pone.0111075

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Peer-reviewed

Research Article

Systemically Administered IgG Anti-Toxin Antibodies Protect the Colonic Mucosa during Infection with Clostridium difficile in the Piglet Model

Ocean R. Cohen,

Affiliation Department of Infectious Disease and Global Health, Tufts Cummings School of Veterinary Medicine, North Grafton, Massachusetts, United States of America
⨯
Jennifer A. Steele,

Affiliation Department of Infectious Disease and Global Health, Tufts Cummings School of Veterinary Medicine, North Grafton, Massachusetts, United States of America
⨯
Quanshun Zhang,

Current address: Institute for In Vitro Sciences, Gaithersburg, Maryland, United States of America

Affiliation Department of Infectious Disease and Global Health, Tufts Cummings School of Veterinary Medicine, North Grafton, Massachusetts, United States of America
⨯
Diane J. Schmidt,

Affiliation Department of Infectious Disease and Global Health, Tufts Cummings School of Veterinary Medicine, North Grafton, Massachusetts, United States of America
⨯
Yuankai Wang,

Current address: Shanghai Key Laboratory of Veterinary Biotechnology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China

Affiliation Department of Infectious Disease and Global Health, Tufts Cummings School of Veterinary Medicine, North Grafton, Massachusetts, United States of America
⨯
Philip E. S. Hamel,

Affiliation Department of Infectious Disease and Global Health, Tufts Cummings School of Veterinary Medicine, North Grafton, Massachusetts, United States of America
⨯
Gillian Beamer,

Affiliation Department of Infectious Disease and Global Health, Tufts Cummings School of Veterinary Medicine, North Grafton, Massachusetts, United States of America
⨯
Bingling Xu,

Affiliation Department of Infectious Disease and Global Health, Tufts Cummings School of Veterinary Medicine, North Grafton, Massachusetts, United States of America
⨯
Saul Tzipori

* E-mail: Saul.Tzipori@tufts.edu

Affiliation Department of Infectious Disease and Global Health, Tufts Cummings School of Veterinary Medicine, North Grafton, Massachusetts, United States of America
⨯

Systemically Administered IgG Anti-Toxin Antibodies Protect the Colonic Mucosa during Infection with Clostridium difficile in the Piglet Model

Ocean R. Cohen,
Jennifer A. Steele,
Quanshun Zhang,
Diane J. Schmidt,
Yuankai Wang,
Philip E. S. Hamel,
Gillian Beamer,
Bingling Xu,
Saul Tzipori

Published: October 27, 2014
https://doi.org/10.1371/journal.pone.0111075

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