Impact of the Superoxide Dismutase 2 Val16Ala Polymorphism on the Relationship between Valproic Acid Exposure and Elevation of γ-Glutamyltransferase in Patients with Epilepsy: A Population Pharmacokinetic-Pharmacodynamic Analysis

Naoki Ogusu; Junji Saruwatari; Hiroo Nakashima; Madoka Noai; Miki Nishimura; Mariko Deguchi; Kentaro Oniki; Norio Yasui-Furukori; Sunao Kaneko; Takateru Ishitsu; Kazuko Nakagaswa

doi:10.1371/journal.pone.0111066

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Peer-reviewed

Research Article

Impact of the Superoxide Dismutase 2 Val16Ala Polymorphism on the Relationship between Valproic Acid Exposure and Elevation of γ-Glutamyltransferase in Patients with Epilepsy: A Population Pharmacokinetic-Pharmacodynamic Analysis

Naoki Ogusu,

Affiliation Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
⨯
Junji Saruwatari ,

* E-mail: junsaru@gpo.kumamoto-u.ac.jp

Affiliation Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
⨯
Hiroo Nakashima,

Affiliation Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
⨯
Madoka Noai,

Affiliation Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
⨯
Miki Nishimura,

Affiliation Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
⨯
Mariko Deguchi,

Affiliation Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
⨯
Kentaro Oniki,

Affiliation Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
⨯
Norio Yasui-Furukori,

Affiliation Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, Japan
⨯
Sunao Kaneko,

Affiliation Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, Japan
⨯
Takateru Ishitsu,

Affiliations Kumamoto Saishunso National Hospital, Kumamoto, Japan, Kumamoto Ezuko Ryoiku Iryo Center, Kumamoto, Japan
⨯
Kazuko Nakagaswa

Affiliations Division of Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan, Center for Clinical Pharmaceutical Sciences, Kumamoto University, Kumamoto, Japan
⨯

Impact of the Superoxide Dismutase 2 Val16Ala Polymorphism on the Relationship between Valproic Acid Exposure and Elevation of γ-Glutamyltransferase in Patients with Epilepsy: A Population Pharmacokinetic-Pharmacodynamic Analysis

Naoki Ogusu,
Junji Saruwatari,
Hiroo Nakashima,
Madoka Noai,
Miki Nishimura,
Mariko Deguchi,
Kentaro Oniki,
Norio Yasui-Furukori,
Sunao Kaneko,
Takateru Ishitsu

Published: November 5, 2014
https://doi.org/10.1371/journal.pone.0111066

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