Plk1 Inhibition Causes Post-Mitotic DNA Damage and Senescence in a Range of Human Tumor Cell Lines

Denise L. Driscoll; Arijit Chakravarty; Doug Bowman; Vaishali Shinde; Kerri Lasky; Judy Shi; Tricia Vos; Bradley Stringer; Ben Amidon; Natalie D'Amore; Marc L. Hyer

doi:10.1371/journal.pone.0111060

Loading metrics

Open Access

Peer-reviewed

Research Article

Plk1 Inhibition Causes Post-Mitotic DNA Damage and Senescence in a Range of Human Tumor Cell Lines

Denise L. Driscoll ,

Contributed equally to this work with: Denise L. Driscoll, Arijit Chakravarty

Affiliation Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, United States of America
⨯
Arijit Chakravarty ,

Contributed equally to this work with: Denise L. Driscoll, Arijit Chakravarty

Affiliation Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, United States of America
⨯
Doug Bowman,

Affiliation Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, United States of America
⨯
Vaishali Shinde,

Affiliation Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, United States of America
⨯
Kerri Lasky,

Affiliation Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, United States of America
⨯
Judy Shi,

Affiliation Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, United States of America
⨯
Tricia Vos,

Affiliation Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, United States of America
⨯
Bradley Stringer,

Affiliation Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, United States of America
⨯
Ben Amidon,

Affiliation Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, United States of America
⨯
Natalie D'Amore,

Affiliation Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, United States of America
⨯
Marc L. Hyer

* E-mail: marc.hyer@takeda.com

Affiliation Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, United States of America
⨯

Plk1 Inhibition Causes Post-Mitotic DNA Damage and Senescence in a Range of Human Tumor Cell Lines

Denise L. Driscoll,
Arijit Chakravarty,
Doug Bowman,
Vaishali Shinde,
Kerri Lasky,
Judy Shi,
Tricia Vos,
Bradley Stringer,
Ben Amidon,
Natalie D'Amore

Published: November 3, 2014
https://doi.org/10.1371/journal.pone.0111060

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

DNA damage
Is the Subject Area "DNA damage" applicable to this article?

Thanks for your feedback.
Cancers and neoplasms
Is the Subject Area "Cancers and neoplasms" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
HT29 cells
Is the Subject Area "HT29 cells" applicable to this article?

Thanks for your feedback.
SW480 cells
Is the Subject Area "SW480 cells" applicable to this article?

Thanks for your feedback.
Cell staining
Is the Subject Area "Cell staining" applicable to this article?

Thanks for your feedback.
Small molecules
Is the Subject Area "Small molecules" applicable to this article?

Thanks for your feedback.