DDX3X Induces Primary EGFR-TKI Resistance Based on Intratumor Heterogeneity in Lung Cancer Cells Harboring EGFR-Activating Mutations

Koichiro Nozaki; Hiroshi Kagamu; Satoshi Shoji; Natsue Igarashi; Aya Ohtsubo; Masaaki Okajima; Satoru Miura; Satoshi Watanabe; Hirohisa Yoshizawa; Ichiei Narita

doi:10.1371/journal.pone.0111019

Loading metrics

Open Access

Peer-reviewed

Research Article

DDX3X Induces Primary EGFR-TKI Resistance Based on Intratumor Heterogeneity in Lung Cancer Cells Harboring EGFR-Activating Mutations

Koichiro Nozaki ,

Contributed equally to this work with: Koichiro Nozaki, Hiroshi Kagamu

Affiliation Division of Respiratory Medicine, Department of Homeostatic Regulation and Development, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
⨯
Hiroshi Kagamu ,

Contributed equally to this work with: Koichiro Nozaki, Hiroshi Kagamu

* E-mail: hkagamu@med.niigata-u.ac.jp

Affiliation Division of Respiratory Medicine, Department of Homeostatic Regulation and Development, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
⨯
Satoshi Shoji,

Affiliation Division of Respiratory Medicine, Department of Homeostatic Regulation and Development, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
⨯
Natsue Igarashi,

Affiliation Division of Respiratory Medicine, Department of Homeostatic Regulation and Development, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
⨯
Aya Ohtsubo,

Affiliation Division of Respiratory Medicine, Department of Homeostatic Regulation and Development, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
⨯
Masaaki Okajima,

Affiliation Division of Respiratory Medicine, Department of Homeostatic Regulation and Development, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
⨯
Satoru Miura,

Affiliation Division of Respiratory Medicine, Department of Homeostatic Regulation and Development, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
⨯
Satoshi Watanabe,

Affiliation Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, Niigata, Japan
⨯
Hirohisa Yoshizawa,

Affiliation Bioscience Medical Research Center, Niigata University Medical and Dental Hospital, Niigata, Japan
⨯
Ichiei Narita

Affiliation Division of Respiratory Medicine, Department of Homeostatic Regulation and Development, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan
⨯

DDX3X Induces Primary EGFR-TKI Resistance Based on Intratumor Heterogeneity in Lung Cancer Cells Harboring EGFR-Activating Mutations

Koichiro Nozaki,
Hiroshi Kagamu,
Satoshi Shoji,
Natsue Igarashi,
Aya Ohtsubo,
Masaaki Okajima,
Satoru Miura,
Satoshi Watanabe,
Hirohisa Yoshizawa,
Ichiei Narita

Published: October 24, 2014
https://doi.org/10.1371/journal.pone.0111019

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Lung and intrathoracic tumors
Is the Subject Area "Lung and intrathoracic tumors" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
EGFR signaling
Is the Subject Area "EGFR signaling" applicable to this article?

Thanks for your feedback.
Phosphorylation
Is the Subject Area "Phosphorylation" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.
Immunoblotting
Is the Subject Area "Immunoblotting" applicable to this article?

Thanks for your feedback.
Phenotypes
Is the Subject Area "Phenotypes" applicable to this article?

Thanks for your feedback.
Cell staining
Is the Subject Area "Cell staining" applicable to this article?

Thanks for your feedback.