Caspase-3 Mediates the Pathogenic Effect of Yersinia pestis YopM in Liver of C57BL/6 Mice and Contributes to YopM's Function in Spleen

Zhan Ye; Amanda A. Gorman; Annette M. Uittenbogaard; Tanya Myers-Morales; Alan M. Kaplan; Donald A. Cohen; Susan C. Straley

doi:10.1371/journal.pone.0110956

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Peer-reviewed

Research Article

Caspase-3 Mediates the Pathogenic Effect of Yersinia pestis YopM in Liver of C57BL/6 Mice and Contributes to YopM's Function in Spleen

Zhan Ye,

Current address: Department of Pathology and Laboratory Medicine, University of Kentucky, Lexington, KY, United States of America

Affiliation Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY, United States of America
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Amanda A. Gorman,

Current address: Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, United States of America

Affiliation Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY, United States of America
⨯
Annette M. Uittenbogaard,

Current address: Department of Ophthalmology and Visual Sciences, University of Kentucky, United States of America

Affiliation Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY, United States of America
⨯
Tanya Myers-Morales,

Affiliation Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY, United States of America
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Alan M. Kaplan,

Affiliation Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY, United States of America
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Donald A. Cohen,

Affiliation Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY, United States of America
⨯
Susan C. Straley

* E-mail: scstra01@uky.edu

Affiliation Department of Microbiology, Immunology, and Molecular Genetics, University of Kentucky, Lexington, KY, United States of America
⨯

Caspase-3 Mediates the Pathogenic Effect of Yersinia pestis YopM in Liver of C57BL/6 Mice and Contributes to YopM's Function in Spleen

Zhan Ye,
Amanda A. Gorman,
Annette M. Uittenbogaard,
Tanya Myers-Morales,
Alan M. Kaplan,
Donald A. Cohen,
Susan C. Straley

Published: November 5, 2014
https://doi.org/10.1371/journal.pone.0110956

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Yersinia pestis
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Spleen
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Inflammation
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Apoptosis
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Genetically modified animals
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Liver
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