Advanced Glycation End-Products Reduce Collagen Molecular Sliding to Affect Collagen Fibril Damage Mechanisms but Not Stiffness

• Gion Fessel,

  Affiliations Department of Orthopedics, Balgrist University Hospital, University of Zurich, Zurich, Switzerland, Institute for Biomechanics, ETH Zurich, Zurich, Switzerland

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• Yufei Li,

  Affiliations Department of Orthopedics, Balgrist University Hospital, University of Zurich, Zurich, Switzerland, Institute for Biomechanics, ETH Zurich, Zurich, Switzerland

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• Vincent Diederich,

  Affiliation Institute for Chemical and Bioengineering, ETH Zurich, Zurich, Switzerland

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• Manuel Guizar-Sicairos,

  Affiliation Paul Scherrer Institute, Villigen, Switzerland

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• Philipp Schneider,

  Affiliations Institute for Biomechanics, ETH Zurich, Zurich, Switzerland, Faculty of Engineering and the Environment, University of Southampton, Southampton, United Kingdom

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• David R. Sell,

  Affiliation Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Vincent M. Monnier,

  Affiliations Department of Pathology, Case Western Reserve University, Cleveland, Ohio, United States of America, Department of Biochemistry, Case Western Reserve University, Cleveland, Ohio, United States of America

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• Jess G. Snedeker

  * E-mail: jsnedeker@research.balgrist.ch

  Affiliations Department of Orthopedics, Balgrist University Hospital, University of Zurich, Zurich, Switzerland, Institute for Biomechanics, ETH Zurich, Zurich, Switzerland

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