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Open Access
Peer-reviewed
Research Article
Discovery and Characterization of a Potent and Selective Inhibitor of Aedes aegypti Inward Rectifier Potassium Channels
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Rene Raphemot,
Affiliations Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, United States of America, Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, United States of America
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Matthew F. Rouhier,
Affiliation Department of Entomology, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH, United States of America
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Daniel R. Swale,
Affiliation Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, United States of America
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Emily Days,
Affiliation Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN, United States of America
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C. David Weaver,
Affiliations Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, United States of America, Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN, United States of America
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Kimberly M. Lovell,
Affiliations Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, United States of America, Department of Chemistry, Vanderbilt University School of Medicine, Nashville TN, United States of America
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Leah C. Konkel,
Affiliations Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, United States of America, Department of Chemistry, Vanderbilt University School of Medicine, Nashville TN, United States of America
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Darren W. Engers,
Affiliations Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, United States of America, Department of Chemistry, Vanderbilt University School of Medicine, Nashville TN, United States of America
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Sean F. Bollinger,
Affiliations Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, United States of America, Department of Chemistry, Vanderbilt University School of Medicine, Nashville TN, United States of America
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Corey Hopkins,
Affiliations Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, United States of America, Institute for Global Health, Vanderbilt University, Nashville, TN, United States of America, Department of Chemistry, Vanderbilt University School of Medicine, Nashville TN, United States of America
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Peter M. Piermarini ,
* E-mail: piermarini.1@osu.edu (PMP); jerod.s.denton@vanderbilt.edu (JSD)
Affiliation Department of Entomology, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, OH, United States of America
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Jerod S. Denton
* E-mail: piermarini.1@osu.edu (PMP); jerod.s.denton@vanderbilt.edu (JSD)
Affiliations Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN, United States of America, Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, United States of America, Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, TN, United States of America, Institute for Global Health, Vanderbilt University, Nashville, TN, United States of America
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Discovery and Characterization of a Potent and Selective Inhibitor of Aedes aegypti Inward Rectifier Potassium Channels
- Rene Raphemot,
- Matthew F. Rouhier,
- Daniel R. Swale,
- Emily Days,
- C. David Weaver,
- Kimberly M. Lovell,
- Leah C. Konkel,
- Darren W. Engers,
- Sean F. Bollinger,
- Corey Hopkins
- Published: November 6, 2014
- https://doi.org/10.1371/journal.pone.0110772