Altered B Cell Homeostasis and Toll-Like Receptor 9-Driven Response in Type 1 Diabetes Carriers of the C1858T PTPN22 Allelic Variant: Implications in the Disease Pathogenesis

• Elena Gianchecchi,

  Affiliation Autoimmunity Laboratory, Immunology and Pharmacotherapy Area, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

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• Antonino Crinò,

  Affiliation Division of Endocrinology, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

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• Ezio Giorda,

  Affiliation B cell Development Laboratory, Immunology and Pharmacotherapy Area, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

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• Rosa Luciano,

  Affiliation Research Laboratories, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

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• Valentina Perri,

  Affiliation Autoimmunity Laboratory, Immunology and Pharmacotherapy Area, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

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• Anna Lo Russo,

  Affiliation Autoimmunity Laboratory, Immunology and Pharmacotherapy Area, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

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• Marco Cappa,

  Affiliation Division of Endocrinology, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

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• M. Manuela Rosado,

  Affiliation B cell Development Laboratory, Immunology and Pharmacotherapy Area, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

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• Alessandra Fierabracci

  * E-mail: alessandra.fierabracci@opbg.net

  Affiliation Autoimmunity Laboratory, Immunology and Pharmacotherapy Area, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

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