Targeting of Repeated Sequences Unique to a Gene Results in Significant Increases in Antisense Oligonucleotide Potency

Open Access

Peer-reviewed

Research Article

Timothy A. Vickers ,

* E-mail: tvickers@isisph.com

Affiliation Department of Core Antisense Research, ISIS Pharmaceuticals, Inc., Carlsbad, California, United States of America
⨯
Susan M. Freier,

Affiliation Department of Core Antisense Research, ISIS Pharmaceuticals, Inc., Carlsbad, California, United States of America
⨯
Huynh-Hoa Bui,

Affiliation Department of Core Antisense Research, ISIS Pharmaceuticals, Inc., Carlsbad, California, United States of America
⨯
Andrew Watt,

Affiliation Department of Core Antisense Research, ISIS Pharmaceuticals, Inc., Carlsbad, California, United States of America
⨯
Stanley T. Crooke

Affiliation Department of Core Antisense Research, ISIS Pharmaceuticals, Inc., Carlsbad, California, United States of America
⨯

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Introns
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Ribonucleases
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Repeated sequences
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Small nuclear RNA
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Transfection
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Antisense RNA
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RNA-binding proteins
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RNA structure
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