A Two-Step Strategy to Enhance Activity of Low Potency Peptides

Jamie R. Doyle; Benjamin N. Harwood; Subrahmanian Tarakkad Krishnaji; Vijay M. Krishnamurthy; Wei-En Lin; Jean-Philippe Fortin; Krishna Kumar; Alan S. Kopin

doi:10.1371/journal.pone.0110502

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Peer-reviewed

Research Article

A Two-Step Strategy to Enhance Activity of Low Potency Peptides

Jamie R. Doyle ,

Contributed equally to this work with: Jamie R. Doyle, Benjamin N. Harwood

¶These authors are co-first authors on this work.

Affiliation Tufts Medical Center, Molecular Cardiology Research Institute, Molecular Pharmacology Research Center, Boston, Massachusetts, United States of America
⨯
Benjamin N. Harwood ,

Contributed equally to this work with: Jamie R. Doyle, Benjamin N. Harwood

¶These authors are co-first authors on this work.

Affiliations Tufts Medical Center, Molecular Cardiology Research Institute, Molecular Pharmacology Research Center, Boston, Massachusetts, United States of America, Program in Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, United States of America
⨯
Subrahmanian Tarakkad Krishnaji,

Affiliation Tufts University, Department of Chemistry, Medford, Massachusetts, United States of America
⨯
Vijay M. Krishnamurthy,

Affiliation Tufts University, Department of Chemistry, Medford, Massachusetts, United States of America
⨯
Wei-En Lin,

Affiliation Tufts University, Department of Chemistry, Medford, Massachusetts, United States of America
⨯
Jean-Philippe Fortin,

Affiliation Tufts Medical Center, Molecular Cardiology Research Institute, Molecular Pharmacology Research Center, Boston, Massachusetts, United States of America
⨯
Krishna Kumar ,

* E-mail: akopin@tuftsmedicalcenter.org (ASK); krishna.kumar@tufts.edu (KK)

Affiliation Tufts University, Department of Chemistry, Medford, Massachusetts, United States of America
⨯
Alan S. Kopin

* E-mail: akopin@tuftsmedicalcenter.org (ASK); krishna.kumar@tufts.edu (KK)

Affiliations Tufts Medical Center, Molecular Cardiology Research Institute, Molecular Pharmacology Research Center, Boston, Massachusetts, United States of America, Program in Genetics, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, United States of America
⨯

A Two-Step Strategy to Enhance Activity of Low Potency Peptides

Jamie R. Doyle,
Benjamin N. Harwood,
Subrahmanian Tarakkad Krishnaji,
Vijay M. Krishnamurthy,
Wei-En Lin,
Jean-Philippe Fortin,
Krishna Kumar,
Alan S. Kopin

Published: November 12, 2014
https://doi.org/10.1371/journal.pone.0110502

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