Rho-Kinase Inhibition Ameliorates Metabolic Disorders through Activation of AMPK Pathway in Mice

Kazuki Noda; Sota Nakajima; Shigeo Godo; Hiroki Saito; Shohei Ikeda; Toru Shimizu; Budbazar Enkhjargal; Yoshihiro Fukumoto; Sohei Tsukita; Tetsuya Yamada; Hideki Katagiri; Hiroaki Shimokawa

doi:10.1371/journal.pone.0110446

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Open Access

Peer-reviewed

Research Article

Rho-Kinase Inhibition Ameliorates Metabolic Disorders through Activation of AMPK Pathway in Mice

Kazuki Noda,

Affiliation Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Sota Nakajima,

Affiliation Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Shigeo Godo,

Affiliation Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Hiroki Saito,

Affiliation Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Shohei Ikeda,

Affiliation Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Toru Shimizu,

Affiliation Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Budbazar Enkhjargal,

Affiliation Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Yoshihiro Fukumoto,

Affiliation Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Sohei Tsukita,

Affiliation Department of Metabolic Diseases, Center for Metabolic Diseases, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Tetsuya Yamada,

Affiliation Department of Metabolic Diseases, Center for Metabolic Diseases, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Hideki Katagiri,

Affiliation Department of Metabolic Diseases, Center for Metabolic Diseases, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯
Hiroaki Shimokawa

* E-mail: shimo@cardio.med.tohoku.ac.jp

Affiliation Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
⨯

Rho-Kinase Inhibition Ameliorates Metabolic Disorders through Activation of AMPK Pathway in Mice

Kazuki Noda,
Sota Nakajima,
Shigeo Godo,
Hiroki Saito,
Shohei Ikeda,
Toru Shimizu,
Budbazar Enkhjargal,
Yoshihiro Fukumoto,
Sohei Tsukita,
Tetsuya Yamada

Published: November 3, 2014
https://doi.org/10.1371/journal.pone.0110446

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