The Synthetic Tryptanthrin Analogue Suppresses STAT3 Signaling and Induces Caspase Dependent Apoptosis via ERK Up Regulation in Human Leukemia HL-60 Cells

Anup S. Pathania; Suresh Kumar; Santosh K. Guru; Shashi Bhushan; Parduman R. Sharma; Sravan K. Aithagani; Parvinder P. Singh; Ram A. Vishwakarma; Ajay Kumar; Fayaz Malik

doi:10.1371/journal.pone.0110411

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Open Access

Peer-reviewed

Research Article

The Synthetic Tryptanthrin Analogue Suppresses STAT3 Signaling and Induces Caspase Dependent Apoptosis via ERK Up Regulation in Human Leukemia HL-60 Cells

Anup S. Pathania,

Affiliations Department of Cancer Pharmacology, Indian Institute of Integrative Medicine, Jammu and Kashmir, India, Academy of Scientific and Innovative Research (AcSIR), New Delhi, India
⨯
Suresh Kumar,

Affiliations Department of Cancer Pharmacology, Indian Institute of Integrative Medicine, Jammu and Kashmir, India, Academy of Scientific and Innovative Research (AcSIR), New Delhi, India
⨯
Santosh K. Guru,

Affiliation Department of Cancer Pharmacology, Indian Institute of Integrative Medicine, Jammu and Kashmir, India
⨯
Shashi Bhushan,

Affiliation Department of Cancer Pharmacology, Indian Institute of Integrative Medicine, Jammu and Kashmir, India
⨯
Parduman R. Sharma,

Affiliation Department of Cancer Pharmacology, Indian Institute of Integrative Medicine, Jammu and Kashmir, India
⨯
Sravan K. Aithagani,

Affiliations Medicinal chemistry division, Indian institute of Integrative Medicine, Jammu and Kashmir, India, Academy of Scientific and Innovative Research (AcSIR), New Delhi, India
⨯
Parvinder P. Singh,

Affiliation Medicinal chemistry division, Indian institute of Integrative Medicine, Jammu and Kashmir, India
⨯
Ram A. Vishwakarma,

Affiliation Medicinal chemistry division, Indian institute of Integrative Medicine, Jammu and Kashmir, India
⨯
Ajay Kumar ,

* E-mail: ajaykmahajan@hotmail.com (AK); fmalik@iiim.ac.in (FM)

Affiliation Department of Cancer Pharmacology, Indian Institute of Integrative Medicine, Jammu and Kashmir, India
⨯
Fayaz Malik

* E-mail: ajaykmahajan@hotmail.com (AK); fmalik@iiim.ac.in (FM)

Affiliations Department of Cancer Pharmacology, Indian Institute of Integrative Medicine, Jammu and Kashmir, India, Experimental Breast Cancer Research Laboratory, University of Michigan North Campus Research Complex, Ann Arbor, Michigan, United States of America
⨯

The Synthetic Tryptanthrin Analogue Suppresses STAT3 Signaling and Induces Caspase Dependent Apoptosis via ERK Up Regulation in Human Leukemia HL-60 Cells

Anup S. Pathania,
Suresh Kumar,
Santosh K. Guru,
Shashi Bhushan,
Parduman R. Sharma,
Sravan K. Aithagani,
Parvinder P. Singh,
Ram A. Vishwakarma,
Ajay Kumar,
Fayaz Malik

Published: November 10, 2014
https://doi.org/10.1371/journal.pone.0110411

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Apoptosis
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Cancer treatment
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Leukemia cells
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Cytotoxicity
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ERK signaling cascade
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Mitochondria
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STAT signaling
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Phosphorylation
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