PLK1 and β-TrCP-Dependent Ubiquitination and Degradation of Rap1GAP Controls Cell Proliferation

Dejie Wang; Pingzhao Zhang; Kun Gao; Yan Tang; Xiaofeng Jin; Yuanyuan Zhang; Qing Yi; Chenji Wang; Long Yu

doi:10.1371/journal.pone.0110296

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Open Access

Peer-reviewed

Research Article

PLK1 and β-TrCP-Dependent Ubiquitination and Degradation of Rap1GAP Controls Cell Proliferation

Dejie Wang ,

Contributed equally to this work with: Dejie Wang, Pingzhao Zhang

Affiliations State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, P.R. China, Department of Gastroenterology, Jiangxi Institute of Gastroenterology & Hepatology, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, P. R. China
⨯
Pingzhao Zhang ,

Contributed equally to this work with: Dejie Wang, Pingzhao Zhang

Affiliations State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, P.R. China, Institutes of Biomedical Sciences, Fudan University, Shanghai, P.R. China
⨯
Kun Gao,

Affiliation State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, P.R. China
⨯
Yan Tang,

Affiliation State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, P.R. China
⨯
Xiaofeng Jin,

Affiliation State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, P.R. China
⨯
Yuanyuan Zhang,

Affiliation State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, P.R. China
⨯
Qing Yi,

Affiliation Department of Lymphoma and Myeloma, Division of Cancer Medicine, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America
⨯
Chenji Wang ,

* E-mail: chenjiwang@fudan.edu.cn (CW); longyu@fudan.edu.cn (LY)

Affiliation State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, P.R. China
⨯
Long Yu

* E-mail: chenjiwang@fudan.edu.cn (CW); longyu@fudan.edu.cn (LY)

Affiliations State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, P.R. China, Institutes of Biomedical Sciences, Fudan University, Shanghai, P.R. China
⨯

PLK1 and β-TrCP-Dependent Ubiquitination and Degradation of Rap1GAP Controls Cell Proliferation

Dejie Wang,
Pingzhao Zhang,
Kun Gao,
Yan Tang,
Xiaofeng Jin,
Yuanyuan Zhang,
Qing Yi,
Chenji Wang,
Long Yu

Published: October 17, 2014
https://doi.org/10.1371/journal.pone.0110296

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