Irisin Promotes Human Umbilical Vein Endothelial Cell Proliferation through the ERK Signaling Pathway and Partly Suppresses High Glucose-Induced Apoptosis

Haibo Song; Fei Wu; Yuan Zhang; Yuzhu Zhang; Fang Wang; Miao Jiang; Zhongde Wang; Mingxiang Zhang; Shiwu Li; Lijun Yang; Xing Li Wang; Taixing Cui; Dongqi Tang

doi:10.1371/journal.pone.0110273

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Open Access

Peer-reviewed

Research Article

Irisin Promotes Human Umbilical Vein Endothelial Cell Proliferation through the ERK Signaling Pathway and Partly Suppresses High Glucose-Induced Apoptosis

Haibo Song,

Affiliations Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan, P.R.China, Shandong University Qilu Hospital Research Center for Cell Therapy, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan, P.R.China, Center for Reproductive Medicine, Zibo Maternal and Child health hospital, Zibo, P.R.China
⨯
Fei Wu,

Affiliations Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan, P.R.China, Shandong University Qilu Hospital Research Center for Cell Therapy, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan, P.R.China
⨯
Yuan Zhang,

Affiliations Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan, P.R.China, Shandong University Qilu Hospital Research Center for Cell Therapy, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan, P.R.China
⨯
Yuzhu Zhang,

Affiliations Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan, P.R.China, Shandong University Qilu Hospital Research Center for Cell Therapy, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan, P.R.China
⨯
Fang Wang,

Affiliation Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan, P.R.China
⨯
Miao Jiang,

Affiliation Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan, P.R.China
⨯
Zhongde Wang,

Affiliation Center for Reproductive Medicine, Zibo Maternal and Child health hospital, Zibo, P.R.China
⨯
Mingxiang Zhang,

Affiliation Shandong University Qilu Hospital Research Center for Cell Therapy, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan, P.R.China
⨯
Shiwu Li,

Affiliation Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan, P.R.China
⨯
Lijun Yang,

Affiliation Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan, P.R.China
⨯
Xing Li Wang,

Affiliation Shandong University Qilu Hospital Research Center for Cell Therapy, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan, P.R.China
⨯
Taixing Cui ,

* E-mail: tangdq@sdu.edu.cn (DT); Taixing.Cui@uscmed.sc.edu (TC)

Affiliations Shandong University Qilu Hospital Research Center for Cell Therapy, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan, P.R.China, Department of Cell Biology and Anatomy, University of South Carolina, Columbia, South Carolina, United States of America
⨯
Dongqi Tang

* E-mail: tangdq@sdu.edu.cn (DT); Taixing.Cui@uscmed.sc.edu (TC)

Affiliations Center for Stem Cell & Regenerative Medicine, The Second Hospital of Shandong University, Jinan, P.R.China, Shandong University Qilu Hospital Research Center for Cell Therapy, Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital of Shandong University, Jinan, P.R.China
⨯

Irisin Promotes Human Umbilical Vein Endothelial Cell Proliferation through the ERK Signaling Pathway and Partly Suppresses High Glucose-Induced Apoptosis

Haibo Song,
Fei Wu,
Yuan Zhang,
Yuzhu Zhang,
Fang Wang,
Miao Jiang,
Zhongde Wang,
Mingxiang Zhang,
Shiwu Li,
Lijun Yang

Published: October 22, 2014
https://doi.org/10.1371/journal.pone.0110273

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Apoptosis
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ERK signaling cascade
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Endothelial cells
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Thymidines
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Cell proliferation
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Homeostasis
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Cell metabolism
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Umbilical veins
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