Proximal Tubule Epithelial Cell Specific Ablation of the Spermidine/Spermine N1-Acetyltransferase Gene Reduces the Severity of Renal Ischemia/Reperfusion Injury

Kamyar Zahedi; Sharon Barone; Yang Wang; Tracy Murray-Stewart; Prabir Roy-Chaudhury; Roger D. Smith; Robert A. Casero Jr; Manoocher Soleimani

doi:10.1371/journal.pone.0110161

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Research Article

Proximal Tubule Epithelial Cell Specific Ablation of the Spermidine/Spermine N¹-Acetyltransferase Gene Reduces the Severity of Renal Ischemia/Reperfusion Injury

Kamyar Zahedi ,

* E-mail: zahedika@ucmail.uc.edu

Affiliations Division of Nephrology and Hypertension, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, Veterans Affair Medical Center, Cincinnati, Ohio, United States of America
⨯
Sharon Barone,

Affiliations Division of Nephrology and Hypertension, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, Veterans Affair Medical Center, Cincinnati, Ohio, United States of America
⨯
Yang Wang,

Affiliation Division of Nephrology and Hypertension, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
⨯
Tracy Murray-Stewart,

Affiliation The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
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Prabir Roy-Chaudhury,

Affiliation Division of Nephrology and Hypertension, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
⨯
Roger D. Smith,

Affiliation Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America
⨯
Robert A. Casero Jr,

Affiliation The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Manoocher Soleimani

Affiliations Division of Nephrology and Hypertension, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States of America, Veterans Affair Medical Center, Cincinnati, Ohio, United States of America
⨯

Proximal Tubule Epithelial Cell Specific Ablation of the Spermidine/Spermine N¹-Acetyltransferase Gene Reduces the Severity of Renal Ischemia/Reperfusion Injury

Kamyar Zahedi,
Sharon Barone,
Yang Wang,
Tracy Murray-Stewart,
Prabir Roy-Chaudhury,
Roger D. Smith,
Robert A. Casero Jr,
Manoocher Soleimani

Published: November 12, 2014
https://doi.org/10.1371/journal.pone.0110161

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