An Active Component of Achyranthes bidentata Polypeptides Provides Neuroprotection through Inhibition of Mitochondrial-Dependent Apoptotic Pathway in Cultured Neurons and in Animal Models of Cerebral Ischemia

Shu Yu; Caiping Wang; Qiong Cheng; Hui Xu; Shibo Zhang; Lu Li; Qi Zhang; Xiaosong Gu; Fei Ding

doi:10.1371/journal.pone.0109923

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Research Article

An Active Component of Achyranthes bidentata Polypeptides Provides Neuroprotection through Inhibition of Mitochondrial-Dependent Apoptotic Pathway in Cultured Neurons and in Animal Models of Cerebral Ischemia

Shu Yu ,

Contributed equally to this work with: Shu Yu, Caiping Wang

Affiliation Jiangsu Key Laboratory of Neuroregeneration, Collaborative Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China
⨯
Caiping Wang ,

Contributed equally to this work with: Shu Yu, Caiping Wang

Affiliation Jiangsu Key Laboratory of Neuroregeneration, Collaborative Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China
⨯
Qiong Cheng,

Affiliation Jiangsu Key Laboratory of Neuroregeneration, Collaborative Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China
⨯
Hui Xu,

Affiliation Jiangsu Key Laboratory of Neuroregeneration, Collaborative Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China
⨯
Shibo Zhang,

Affiliation Jiangsu Key Laboratory of Neuroregeneration, Collaborative Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China
⨯
Lu Li,

Affiliation Jiangsu Key Laboratory of Neuroregeneration, Collaborative Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China
⨯
Qi Zhang,

Affiliation Jiangsu Key Laboratory of Neuroregeneration, Collaborative Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China
⨯
Xiaosong Gu,

Affiliation Jiangsu Key Laboratory of Neuroregeneration, Collaborative Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China
⨯
Fei Ding

* E-mail: dingfei@ntu.edu.cn

Affiliation Jiangsu Key Laboratory of Neuroregeneration, Collaborative Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China
⨯

An Active Component of Achyranthes bidentata Polypeptides Provides Neuroprotection through Inhibition of Mitochondrial-Dependent Apoptotic Pathway in Cultured Neurons and in Animal Models of Cerebral Ischemia

Shu Yu,
Caiping Wang,
Qiong Cheng,
Hui Xu,
Shibo Zhang,
Lu Li,
Qi Zhang,
Xiaosong Gu,
Fei Ding

Published: October 15, 2014
https://doi.org/10.1371/journal.pone.0109923

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Apoptosis
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Neurons
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Mitochondria
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Cerebral ischemia
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High performance liquid chromatography
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