Morphine and Clonidine Combination Therapy Improves Therapeutic Window in Mice: Synergy in Antinociceptive but Not in Sedative or Cardiovascular Effects

• Laura S. Stone ,

  * E-mail: laura.s.stone@mcgill.ca

  Affiliations Alan Edwards Centre for Research on Pain, McGill University, Montreal, Quebec, Canada, Faculty of Dentistry, McGill University, Montreal, Quebec, Canada, Department of Anesthesiology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada, Department of Pharmacology and Therapeutics, Faculty of Medicine, McGill University, Montreal, Quebec, Canada, Department of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada

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• Jonathan P. German,

  Affiliation Department of Neuroscience, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America

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• Kelly F. Kitto,

  Affiliation Department of Neuroscience, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America

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• Carolyn A. Fairbanks,

  Affiliations Department of Pharmaceutics, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, United States of America, Department of Neuroscience, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America, Department of Pharmacology, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America

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• George L. Wilcox

  Affiliations Department of Neuroscience, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America, Department of Pharmacology, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America, Department of Dermatology, Medical School, University of Minnesota, Minneapolis, Minnesota, United States of America

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