A Single Intramuscular Vaccination of Mice with the HSV-1 VC2 Virus with Mutations in the Glycoprotein K and the Membrane Protein UL20 Confers Full Protection against Lethal Intravaginal Challenge with Virulent HSV-1 and HSV-2 Strains

Brent A. Stanfield; Jacque Stahl; Vladimir N. Chouljenko; Ramesh Subramanian; Anu-Susan Charles; Ahmad A. Saied; Jason D. Walker; Konstantin G. Kousoulas

doi:10.1371/journal.pone.0109890

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Research Article

A Single Intramuscular Vaccination of Mice with the HSV-1 VC2 Virus with Mutations in the Glycoprotein K and the Membrane Protein UL20 Confers Full Protection against Lethal Intravaginal Challenge with Virulent HSV-1 and HSV-2 Strains

Brent A. Stanfield,

Affiliation Division of Biotechnology & Molecular Medicine and Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, United States of America
⨯
Jacque Stahl,

Affiliation Division of Biotechnology & Molecular Medicine and Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, United States of America
⨯
Vladimir N. Chouljenko,

Affiliation Division of Biotechnology & Molecular Medicine and Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, United States of America
⨯
Ramesh Subramanian,

Affiliation Division of Biotechnology & Molecular Medicine and Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, United States of America
⨯
Anu-Susan Charles,

Affiliation Division of Biotechnology & Molecular Medicine and Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, United States of America
⨯
Ahmad A. Saied,

Affiliation Division of Biotechnology & Molecular Medicine and Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, United States of America
⨯
Jason D. Walker,

Affiliation Division of Biotechnology & Molecular Medicine and Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, United States of America
⨯
Konstantin G. Kousoulas

* E-mail: vtgusk@lsu.edu

Affiliation Division of Biotechnology & Molecular Medicine and Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, United States of America
⨯

A Single Intramuscular Vaccination of Mice with the HSV-1 VC2 Virus with Mutations in the Glycoprotein K and the Membrane Protein UL20 Confers Full Protection against Lethal Intravaginal Challenge with Virulent HSV-1 and HSV-2 Strains

Brent A. Stanfield,
Jacque Stahl,
Vladimir N. Chouljenko,
Ramesh Subramanian,
Anu-Susan Charles,
Ahmad A. Saied,
Jason D. Walker,
Konstantin G. Kousoulas

Published: October 28, 2014
https://doi.org/10.1371/journal.pone.0109890

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