THDP17 Decreases Ammonia Production through Glutaminase Inhibition. A New Drug for Hepatic Encephalopathy Therapy

M. Mar Díaz-Herrero; José A. del Campo; Pilar Carbonero-Aguilar; José M. Vega-Pérez; Fernando Iglesias-Guerra; Ignacio Periñán; Francisco J. Miñano; Juan Bautista; Manuel Romero-Gómez

doi:10.1371/journal.pone.0109787

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Open Access

Peer-reviewed

Research Article

THDP17 Decreases Ammonia Production through Glutaminase Inhibition. A New Drug for Hepatic Encephalopathy Therapy

M. Mar Díaz-Herrero ,

Contributed equally to this work with: M. Mar Díaz-Herrero, José A. del Campo

Affiliation Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Sevilla, Sevilla, Spain
⨯
José A. del Campo ,

Contributed equally to this work with: M. Mar Díaz-Herrero, José A. del Campo

Affiliation Unidad de Gestión Clínica de Enfermedades Digestivas & Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Hospital Universitario de Valme, Sevilla, Spain
⨯
Pilar Carbonero-Aguilar,

Affiliation Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Sevilla, Sevilla, Spain
⨯
José M. Vega-Pérez,

Affiliation Departamento de Química Orgánica y Química Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, Sevilla, Spain
⨯
Fernando Iglesias-Guerra,

Affiliation Departamento de Química Orgánica y Química Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, Sevilla, Spain
⨯
Ignacio Periñán,

Affiliation Departamento de Química Orgánica y Química Farmacéutica, Facultad de Farmacia, Universidad de Sevilla, Sevilla, Spain
⨯
Francisco J. Miñano,

Affiliation Unidad de Farmacología Experimental y Clínica (UFEC), Hospital Universitario de Valme, Universidad de Sevilla, Sevilla, Spain
⨯
Juan Bautista ,

* E-mail: jdbaut@us.es (JDB); mromerogomez@us.es (MRG)

Affiliation Departamento de Bioquímica y Biología Molecular, Facultad de Farmacia, Universidad de Sevilla, Sevilla, Spain
⨯
Manuel Romero-Gómez

* E-mail: jdbaut@us.es (JDB); mromerogomez@us.es (MRG)

Affiliation Unidad de Gestión Clínica de Enfermedades Digestivas & Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Hospital Universitario de Valme, Sevilla, Spain
⨯

THDP17 Decreases Ammonia Production through Glutaminase Inhibition. A New Drug for Hepatic Encephalopathy Therapy

M. Mar Díaz-Herrero,
José A. del Campo,
Pilar Carbonero-Aguilar,
José M. Vega-Pérez,
Fernando Iglesias-Guerra,
Ignacio Periñán,
Francisco J. Miñano,
Juan Bautista,
Manuel Romero-Gómez

Published: October 17, 2014
https://doi.org/10.1371/journal.pone.0109787

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