Covariance of Charged Amino Acids at Positions 322 and 440 of HIV-1 Env Contributes to Coreceptor Specificity of Subtype B Viruses, and Can Be Used to Improve the Performance of V3 Sequence-Based Coreceptor Usage Prediction Algorithms

• Kieran Cashin,

  Affiliations Center for Biomedical Research, Burnet Institute, Melbourne, Australia, Department of Microbiology and Immunology, University of Melbourne, Melbourne, Australia

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• Jasminka Sterjovski,

  Affiliation Center for Biomedical Research, Burnet Institute, Melbourne, Australia

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• Katherine L. Harvey,

  Affiliations Center for Biomedical Research, Burnet Institute, Melbourne, Australia, Department of Microbiology and Immunology, University of Melbourne, Melbourne, Australia

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• Paul A. Ramsland,

  Affiliations Center for Biomedical Research, Burnet Institute, Melbourne, Australia, Department of Surgery (Austin Health), University of Melbourne, Melbourne, Australia, Department of Immunology, Monash University, Melbourne, Australia, School of Biomedical Sciences, CHIRI Biosciences, Faculty of Health Sciences, Curtin University, Perth, Australia

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• Melissa J. Churchill,

  Affiliations Center for Biomedical Research, Burnet Institute, Melbourne, Australia, Department of Microbiology, Monash University, Melbourne, Australia, Department of Medicine, Monash University, Melbourne, Australia

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• Paul R. Gorry

  * E-mail: gorry@burnet.edu.au

  Affiliations Center for Biomedical Research, Burnet Institute, Melbourne, Australia, Department of Microbiology and Immunology, University of Melbourne, Melbourne, Australia, Department of Infectious Diseases, Monash University, Melbourne, Australia

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