Leptin Downregulates Aggrecan through the p38-ADAMST Pathway in Human Nucleus Pulposus Cells

Open Access

Peer-reviewed

Research Article

Zheng Li ,

Contributed equally to this work with: Zheng Li, Xin Yu

Affiliation Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China
⨯
Xin Yu ,

Contributed equally to this work with: Zheng Li, Xin Yu

Affiliations Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Xicheng District, Beijing, China
⨯
Jinqian Liang,

Affiliation Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China
⨯
William Ka Kei Wu,

Affiliation Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong
⨯
Jun Yu,

Affiliation Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Hong Kong
⨯
Jianxiong Shen

* E-mail: shenjianxiong@medmail.com.cn

Affiliation Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Beijing, China
⨯

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Leptin
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Obesity
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MAPK signaling cascades
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Small interfering RNA
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Protein expression
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Gene expression
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Pathogenesis
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Reverse transcriptase-polymerase chain reaction
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