Timely Inhibition of Notch Signaling by DAPT Promotes Cardiac Differentiation of Murine Pluripotent Stem Cells

Yinan Liu; Peng Li; Kaiyu Liu; Qihua He; Shuo Han; Xiaofeng Sun; Tao Li; Li Shen

doi:10.1371/journal.pone.0109588

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Open Access

Peer-reviewed

Research Article

Timely Inhibition of Notch Signaling by DAPT Promotes Cardiac Differentiation of Murine Pluripotent Stem Cells

Yinan Liu ,

Contributed equally to this work with: Yinan Liu, Peng Li

Affiliation Stem Cell Research Center, Department of Cell Biology, School of Basic Medical Sciences, Peking University, Haidian District, Beijing, China
⨯
Peng Li ,

Contributed equally to this work with: Yinan Liu, Peng Li

Affiliation Stem Cell Research Center, Department of Cell Biology, School of Basic Medical Sciences, Peking University, Haidian District, Beijing, China
⨯
Kaiyu Liu,

Affiliation Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University, Haidian District, Beijing, China
⨯
Qihua He,

Affiliation Center of Medical and Health Analysis, School of Basic Medical Sciences, Peking University, Haidian District, Beijing, China
⨯
Shuo Han,

Affiliation Stem Cell Research Center, Department of Cell Biology, School of Basic Medical Sciences, Peking University, Haidian District, Beijing, China
⨯
Xiaofeng Sun,

Affiliation Department of histology and embryology, Institute of Chinese Medicine, Hunan University of Chinese Medicine, Science Garden District of Hanpu, Changsha, Hunan, China
⨯
Tao Li ,

* E-mail: litao@zjnu.cn (TL); shenli@bjmu.edu.cn (LS)

Affiliation Department of Biology, College of Chemistry and Life Sciences, Zhejiang Normal University, Jinhua, Zhejiang, China
⨯
Li Shen

* E-mail: litao@zjnu.cn (TL); shenli@bjmu.edu.cn (LS)

Affiliation Stem Cell Research Center, Department of Cell Biology, School of Basic Medical Sciences, Peking University, Haidian District, Beijing, China
⨯

Timely Inhibition of Notch Signaling by DAPT Promotes Cardiac Differentiation of Murine Pluripotent Stem Cells

Yinan Liu,
Peng Li,
Kaiyu Liu,
Qihua He,
Shuo Han,
Xiaofeng Sun,
Tao Li,
Li Shen

Published: October 14, 2014
https://doi.org/10.1371/journal.pone.0109588

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Notch signaling
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Cardiomyocytes
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Induced pluripotent stem cells
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