The Gene Expression Response of Chronic Lymphocytic Leukemia Cells to IL-4 Is Specific, Depends on ZAP-70 Status and Is Differentially Affected by an NFκB Inhibitor

Natalia Ruiz-Lafuente; María-José Alcaraz-García; Silvia Sebastián-Ruiz; Joaquín Gómez-Espuch; Consuelo Funes; José-María Moraleda; María-Carmen García-Garay; Natividad Montes-Barqueros; Alfredo Minguela; María-Rocío Álvarez-López; Antonio Parrado

doi:10.1371/journal.pone.0109533

Loading metrics

Open Access

Peer-reviewed

Research Article

The Gene Expression Response of Chronic Lymphocytic Leukemia Cells to IL-4 Is Specific, Depends on ZAP-70 Status and Is Differentially Affected by an NFκB Inhibitor

Natalia Ruiz-Lafuente ,

Contributed equally to this work with: Natalia Ruiz-Lafuente, María-José Alcaraz-García

Affiliations Servicio de Inmunología, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain, Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Murcia, Spain
⨯
María-José Alcaraz-García ,

Contributed equally to this work with: Natalia Ruiz-Lafuente, María-José Alcaraz-García

Affiliations Servicio de Inmunología, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain, Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Murcia, Spain
⨯
Silvia Sebastián-Ruiz,

Affiliations Servicio de Inmunología, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain, Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Murcia, Spain
⨯
Joaquín Gómez-Espuch,

Affiliations Servicio de Hematología y Hemoterapia, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain, Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Murcia, Spain
⨯
Consuelo Funes,

Affiliations Servicio de Hematología y Hemoterapia, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain, Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Murcia, Spain
⨯
José-María Moraleda,

Affiliations Servicio de Hematología y Hemoterapia, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain, Universidad de Murcia, Murcia, Spain, Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Murcia, Spain
⨯
María-Carmen García-Garay,

Affiliation Servicio de Hematología y Hemoterapia, Hospital General Universitario Santa Lucía, Cartagena, Spain
⨯
Natividad Montes-Barqueros,

Affiliations Servicio de Inmunología, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain, Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Murcia, Spain
⨯
Alfredo Minguela,

Affiliations Servicio de Inmunología, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain, Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas, Murcia, Spain, Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Murcia, Spain
⨯
María-Rocío Álvarez-López,

Affiliations Servicio de Inmunología, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain, Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas, Murcia, Spain, Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Murcia, Spain
⨯
Antonio Parrado

* E-mail: antonio.parrado@carm.es

Affiliations Servicio de Inmunología, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain, Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca), Murcia, Spain
⨯

The Gene Expression Response of Chronic Lymphocytic Leukemia Cells to IL-4 Is Specific, Depends on ZAP-70 Status and Is Differentially Affected by an NFκB Inhibitor

Natalia Ruiz-Lafuente,
María-José Alcaraz-García,
Silvia Sebastián-Ruiz,
Joaquín Gómez-Espuch,
Consuelo Funes,
José-María Moraleda,
María-Carmen García-Garay,
Natividad Montes-Barqueros,
Alfredo Minguela,
María-Rocío Álvarez-López

Published: October 3, 2014
https://doi.org/10.1371/journal.pone.0109533

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Chronic lymphoblastic leukemia
Is the Subject Area "Chronic lymphoblastic leukemia" applicable to this article?

Thanks for your feedback.
B cells
Is the Subject Area "B cells" applicable to this article?

Thanks for your feedback.
Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Microarrays
Is the Subject Area "Microarrays" applicable to this article?

Thanks for your feedback.
Cell cultures
Is the Subject Area "Cell cultures" applicable to this article?

Thanks for your feedback.
Gene regulation
Is the Subject Area "Gene regulation" applicable to this article?

Thanks for your feedback.
T cells
Is the Subject Area "T cells" applicable to this article?

Thanks for your feedback.