Personalized Tacrolimus Dose Requirement by CYP3A5 but Not ABCB1 or ACE Genotyping in Both Recipient and Donor after Pediatric Liver Transplantation

Yi-kuan Chen; Long-zhi Han; Feng Xue; Cong-huan Shen; Jun Lu; Tai-hua Yang; Jian-jun Zhang; Qiang Xia

doi:10.1371/journal.pone.0109464

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Peer-reviewed

Research Article

Personalized Tacrolimus Dose Requirement by CYP3A5 but Not ABCB1 or ACE Genotyping in Both Recipient and Donor after Pediatric Liver Transplantation

Yi-kuan Chen ,

Contributed equally to this work with: Yi-kuan Chen, Long-zhi Han

Affiliation Department of Liver Surgery and Liver Transplantation, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China
⨯
Long-zhi Han ,

Contributed equally to this work with: Yi-kuan Chen, Long-zhi Han

Affiliation Department of Liver Surgery and Liver Transplantation, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China
⨯
Feng Xue ,

* E-mail: fengxue6879@163.com (FX); xiaqiang@medmail.com.cn (QX)

Affiliation Department of Liver Surgery and Liver Transplantation, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China
⨯
Cong-huan Shen,

Affiliation Department of Liver Surgery and Liver Transplantation, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China
⨯
Jun Lu,

Affiliation Department of Liver Surgery and Liver Transplantation, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China
⨯
Tai-hua Yang,

Affiliation Department of Liver Surgery and Liver Transplantation, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China
⨯
Jian-jun Zhang,

Affiliation Department of Liver Surgery and Liver Transplantation, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China
⨯
Qiang Xia

* E-mail: fengxue6879@163.com (FX); xiaqiang@medmail.com.cn (QX)

Affiliation Department of Liver Surgery and Liver Transplantation, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China
⨯

Personalized Tacrolimus Dose Requirement by CYP3A5 but Not ABCB1 or ACE Genotyping in Both Recipient and Donor after Pediatric Liver Transplantation

Yi-kuan Chen,
Long-zhi Han,
Feng Xue,
Cong-huan Shen,
Jun Lu,
Tai-hua Yang,
Jian-jun Zhang,
Qiang Xia

Published: October 13, 2014
https://doi.org/10.1371/journal.pone.0109464

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Liver transplantation
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Pediatrics
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Genotyping
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Single nucleotide polymorphisms
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