In Vivo Time-Related Evaluation of a Therapeutic Neutralization Monoclonal Antibody against Lethal Enterovirus 71 Infection in a Mouse Model

Zhiqun Li; Longfa Xu; Delei He; Lisheng Yang; Che Liu; Yixin Chen; James Wai Kuo Shih; Jun Zhang; Qinjian Zhao; Tong Cheng; Ningshao Xia

doi:10.1371/journal.pone.0109391

Loading metrics

Open Access

Peer-reviewed

Research Article

In Vivo Time-Related Evaluation of a Therapeutic Neutralization Monoclonal Antibody against Lethal Enterovirus 71 Infection in a Mouse Model

Zhiqun Li,

Affiliation State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, Xiamen University, Xiamen Fujian, PR China
⨯
Longfa Xu,

Affiliations State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, Xiamen University, Xiamen Fujian, PR China, National Institute of Diagnostics and Vaccine Development in infectious diseases, School of Public Health, Xiamen University, Xiamen Fujian, PR China
⨯
Delei He,

Affiliations State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, Xiamen University, Xiamen Fujian, PR China, National Institute of Diagnostics and Vaccine Development in infectious diseases, School of Public Health, Xiamen University, Xiamen Fujian, PR China
⨯
Lisheng Yang,

Affiliation State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, Xiamen University, Xiamen Fujian, PR China
⨯
Che Liu,

Affiliation State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, Xiamen University, Xiamen Fujian, PR China
⨯
Yixin Chen,

Affiliations State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, Xiamen University, Xiamen Fujian, PR China, National Institute of Diagnostics and Vaccine Development in infectious diseases, School of Public Health, Xiamen University, Xiamen Fujian, PR China
⨯
James Wai Kuo Shih,

Affiliations State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, Xiamen University, Xiamen Fujian, PR China, National Institute of Diagnostics and Vaccine Development in infectious diseases, School of Public Health, Xiamen University, Xiamen Fujian, PR China
⨯
Jun Zhang,

Affiliations State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, Xiamen University, Xiamen Fujian, PR China, National Institute of Diagnostics and Vaccine Development in infectious diseases, School of Public Health, Xiamen University, Xiamen Fujian, PR China
⨯
Qinjian Zhao,

Affiliations State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, Xiamen University, Xiamen Fujian, PR China, National Institute of Diagnostics and Vaccine Development in infectious diseases, School of Public Health, Xiamen University, Xiamen Fujian, PR China
⨯
Tong Cheng ,

* E-mail: tcheng@xmu.edu.cn (TC); nsxia@xmu.edu.cn (NSX)

Affiliations State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, Xiamen University, Xiamen Fujian, PR China, National Institute of Diagnostics and Vaccine Development in infectious diseases, School of Public Health, Xiamen University, Xiamen Fujian, PR China
⨯
Ningshao Xia

* E-mail: tcheng@xmu.edu.cn (TC); nsxia@xmu.edu.cn (NSX)

Affiliations State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Life Sciences, Xiamen University, Xiamen Fujian, PR China, National Institute of Diagnostics and Vaccine Development in infectious diseases, School of Public Health, Xiamen University, Xiamen Fujian, PR China
⨯

In Vivo Time-Related Evaluation of a Therapeutic Neutralization Monoclonal Antibody against Lethal Enterovirus 71 Infection in a Mouse Model

Zhiqun Li,
Longfa Xu,
Delei He,
Lisheng Yang,
Che Liu,
Yixin Chen,
James Wai Kuo Shih,
Jun Zhang,
Qinjian Zhao,
Tong Cheng

Published: October 3, 2014
https://doi.org/10.1371/journal.pone.0109391

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Antibody therapy
Is the Subject Area "Antibody therapy" applicable to this article?

Thanks for your feedback.
Mouse models
Is the Subject Area "Mouse models" applicable to this article?

Thanks for your feedback.
Enzyme-linked immunoassays
Is the Subject Area "Enzyme-linked immunoassays" applicable to this article?

Thanks for your feedback.
Body limbs
Is the Subject Area "Body limbs" applicable to this article?

Thanks for your feedback.
Antibodies
Is the Subject Area "Antibodies" applicable to this article?

Thanks for your feedback.
Immunohistochemistry techniques
Is the Subject Area "Immunohistochemistry techniques" applicable to this article?

Thanks for your feedback.
Animal models of infection
Is the Subject Area "Animal models of infection" applicable to this article?

Thanks for your feedback.
Enterovirus infection
Is the Subject Area "Enterovirus infection" applicable to this article?

Thanks for your feedback.