Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors

Weiru Wang; Kristi Elkins; Angela Oh; Yen-Ching Ho; Jiansheng Wu; Hong Li; Yang Xiao; Mandy Kwong; Mary Coons; Bobby Brillantes; Eric Cheng; Lisa Crocker; Peter S. Dragovich; Deepak Sampath; Xiaozhang Zheng; Kenneth W. Bair; Thomas O'Brien; Lisa D. Belmont

doi:10.1371/journal.pone.0109366

Loading metrics

Open Access

Peer-reviewed

Research Article

Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors

Weiru Wang,

Affiliation Genentech, Inc., South San Francisco, California, United States of America
⨯
Kristi Elkins,

Affiliation Genentech, Inc., South San Francisco, California, United States of America
⨯
Angela Oh,

Affiliation Genentech, Inc., South San Francisco, California, United States of America
⨯
Yen-Ching Ho,

Affiliation Forma Therapeutics, Inc., Watertown, Massachusetts, United States of America
⨯
Jiansheng Wu,

Affiliation Genentech, Inc., South San Francisco, California, United States of America
⨯
Hong Li,

Affiliation Genentech, Inc., South San Francisco, California, United States of America
⨯
Yang Xiao,

Affiliation Genentech, Inc., South San Francisco, California, United States of America
⨯
Mandy Kwong,

Affiliation Genentech, Inc., South San Francisco, California, United States of America
⨯
Mary Coons,

Affiliation Genentech, Inc., South San Francisco, California, United States of America
⨯
Bobby Brillantes,

Affiliation Genentech, Inc., South San Francisco, California, United States of America
⨯
Eric Cheng,

Affiliation Genentech, Inc., South San Francisco, California, United States of America
⨯
Lisa Crocker,

Affiliation Genentech, Inc., South San Francisco, California, United States of America
⨯
Peter S. Dragovich,

Affiliation Genentech, Inc., South San Francisco, California, United States of America
⨯
Deepak Sampath,

Affiliation Genentech, Inc., South San Francisco, California, United States of America
⨯
Xiaozhang Zheng,

Affiliation Forma Therapeutics, Inc., Watertown, Massachusetts, United States of America
⨯
Kenneth W. Bair,

Affiliation Forma Therapeutics, Inc., Watertown, Massachusetts, United States of America
⨯
Thomas O'Brien,

Affiliation Genentech, Inc., South San Francisco, California, United States of America
⨯
[ ... ],
Lisa D. Belmont

* E-mail: belmont.lisa@gene.com

Affiliation Genentech, Inc., South San Francisco, California, United States of America
⨯
[ view all ]
[ view less ]

Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors

Weiru Wang,
Kristi Elkins,
Angela Oh,
Yen-Ching Ho,
Jiansheng Wu,
Hong Li,
Yang Xiao,
Mandy Kwong,
Mary Coons,
Bobby Brillantes

Published: October 6, 2014
https://doi.org/10.1371/journal.pone.0109366

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Crystal structure
Is the Subject Area "Crystal structure" applicable to this article?

Thanks for your feedback.
Cancers and neoplasms
Is the Subject Area "Cancers and neoplasms" applicable to this article?

Thanks for your feedback.
Enzyme structure
Is the Subject Area "Enzyme structure" applicable to this article?

Thanks for your feedback.
Enzyme inhibitors
Is the Subject Area "Enzyme inhibitors" applicable to this article?

Thanks for your feedback.
Imidazole
Is the Subject Area "Imidazole" applicable to this article?

Thanks for your feedback.
Enzymes
Is the Subject Area "Enzymes" applicable to this article?

Thanks for your feedback.
Protein structure
Is the Subject Area "Protein structure" applicable to this article?

Thanks for your feedback.
Protein folding
Is the Subject Area "Protein folding" applicable to this article?

Thanks for your feedback.