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Open Access
Peer-reviewed
Research Article
The Challenges of Genome-Wide Interaction Studies: Lessons to Learn from the Analysis of HDL Blood Levels
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Elisabeth M. van Leeuwen,
Affiliation Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands
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Françoise A. S. Smouter,
Affiliation Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands
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Tony Kam-Thong,
Affiliation Max Planck-Institute of Psychiatry, Munich, Germany
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Nazanin Karbalai,
Affiliation Max Planck-Institute of Psychiatry, Munich, Germany
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Albert V. Smith,
Affiliation Icelandic Heart Association, Kopavogur, Iceland and University of Iceland, Reykjavik, Iceland
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Tamara B. Harris,
Affiliation Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
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Lenore J. Launer,
Affiliation Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, United States of America
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Colleen M. Sitlani,
Affiliation Cardiovascular Health Research Unit and Department of Medicine, University of Washington, Seattle, WA, United States of America
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Guo Li,
Affiliation Cardiovascular Health Research Unit and Department of Medicine, University of Washington, Seattle, WA, United States of America
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Jennifer A. Brody,
Affiliation Cardiovascular Health Research Unit and Department of Medicine, University of Washington, Seattle, WA, United States of America
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Joshua C. Bis,
Affiliation Cardiovascular Health Research Unit and Department of Medicine, University of Washington, Seattle, WA, United States of America
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Charles C. White,
Affiliation Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America
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Alok Jaiswal,
Affiliation Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
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Ben A. Oostra,
Affiliation Department of Clinical Genetics, Erasmus Medical Center, Rotterdam, the Netherlands
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Albert Hofman,
Affiliation Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands
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Fernando Rivadeneira,
Affiliation Departments of Epidemiology and Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands
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Andre G. Uitterlinden,
Affiliation Departments of Epidemiology and Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands
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Eric Boerwinkle,
Affiliation University of Texas Health Science Center School of Public Health, Human Genetics Center, Houston, TX, United States of America
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Christie M. Ballantyne,
Affiliation Department of Medicine, Baylor College of Medicine, Houston, TX, United States of America
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Vilmundur Gudnason,
Affiliation Icelandic Heart Association, Kopavogur, Iceland and University of Iceland, Reykjavik, Iceland
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Bruce M. Psaty,
Affiliation Departments of Epidemiology, Medicine and Health Services, University of Washington, Seattle, WA, United States of America and Group Health Research Institute, Group Health, Seattle, WA, United States of America
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L. Adrienne Cupples,
Affiliations Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, United States of America, Framingham Heart Study, Framingham, Massachusetts, United States of America
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Marjo-Riitta Järvelin,
Affiliations Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, United Kingdom, National Institute for Health and Welfare, Oulu, Finland, Biocenter Oulu, University of Oulu, Oulu, Finland, Institute of Health Sciences, University of Oulu, Oulu, Finland, Unit of Primary Care, Oulu University Hospital, Oulu, Finland
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Samuli Ripatti,
Affiliations Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom, Hjelt Institute, University of Helsinki, Helsinki, Finland
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Aaron Isaacs,
Affiliation Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands
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Bertram Müller-Myhsok,
Affiliations Max Planck-Institute of Psychiatry, Munich, Germany, Munich Cluster für Systems Neurology (Synergy), Munich, Germany, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom
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Lennart C. Karssen,
Affiliation Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands
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Cornelia M. van Duijn
* E-mail: c.vanduijn@erasmusmc.nl
Affiliation Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands
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The Challenges of Genome-Wide Interaction Studies: Lessons to Learn from the Analysis of HDL Blood Levels
- Elisabeth M. van Leeuwen,
- Françoise A. S. Smouter,
- Tony Kam-Thong,
- Nazanin Karbalai,
- Albert V. Smith,
- Tamara B. Harris,
- Lenore J. Launer,
- Colleen M. Sitlani,
- Guo Li,
- Jennifer A. Brody
- Published: October 20, 2014
- https://doi.org/10.1371/journal.pone.0109290