Ischemia-Related Subcellular Redistribution of Sodium Channels Enhances the Proarrhythmic Effect of Class I Antiarrhythmic Drugs: A Simulation Study

• Kunichika Tsumoto ,

  * E-mail: tsumoto@pharma2.med.osaka-u.ac.jp (KT); ykurachi@pharma2.med.osaka-u.ac.jp (YK)

  Affiliation Department of Pharmacology, Graduate school of Medicine, Osaka University, Suita, Japan

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• Takashi Ashihara,

  Affiliation Department of Cardiovascular Medicine, Shiga University of Medical Science, Otsu, Japan

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• Ryo Haraguchi,

  Affiliation Department of Medical Informatics, National Cerebral and Cardiovascular Center, Suita, Japan

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• Kazuo Nakazawa,

  Affiliation Laboratory of Biomedical Science and Information Management, Research Institute, National Cerebral and Cardiovascular Center, Suita, Japan

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• Yoshihisa Kurachi

  * E-mail: tsumoto@pharma2.med.osaka-u.ac.jp (KT); ykurachi@pharma2.med.osaka-u.ac.jp (YK)

  Affiliations Department of Pharmacology, Graduate school of Medicine, Osaka University, Suita, Japan, Center for Advanced Medical Engineering and Informatics, Osaka University, Suita, Japan

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