Synergy between Sphingosine 1-Phosphate and Lipopolysaccharide Signaling Promotes an Inflammatory, Angiogenic and Osteogenic Response in Human Aortic Valve Interstitial Cells

• Isabel Fernández-Pisonero ,

  Contributed equally to this work with: Isabel Fernández-Pisonero, Javier López

  Affiliation Instituto de Biología y Genética Molecular (CSIC-Universidad Valladolid), Valladolid, Spain

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• Javier López ,

  Contributed equally to this work with: Isabel Fernández-Pisonero, Javier López

  Affiliation Cardiology Department, Instituto Ciencias del Corazón (ICICOR) Hospital Clínico Universitario, Valladolid, Spain

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• Esther Onecha,

  Affiliation Instituto de Biología y Genética Molecular (CSIC-Universidad Valladolid), Valladolid, Spain

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• Ana I. Dueñas †,

  † Deceased.

  Affiliation Research Unit, Hospital Clínico Universitario, Valladolid, Spain

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• Patricia Maeso,

  Affiliation Instituto de Biología y Genética Molecular (CSIC-Universidad Valladolid), Valladolid, Spain

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• Mariano Sánchez Crespo,

  Affiliation Instituto de Biología y Genética Molecular (CSIC-Universidad Valladolid), Valladolid, Spain

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• José Alberto San Román,

  Affiliation Cardiology Department, Instituto Ciencias del Corazón (ICICOR) Hospital Clínico Universitario, Valladolid, Spain

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• Carmen García-Rodríguez

  * E-mail: cgarcia@ibgm.uva.es

  Affiliation Instituto de Biología y Genética Molecular (CSIC-Universidad Valladolid), Valladolid, Spain

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