Gemcitabine Induces Poly (ADP-Ribose) Polymerase-1 (PARP-1) Degradation through Autophagy in Pancreatic Cancer

Yufeng Wang; Yasuhiro Kuramitsu; Kazuhiro Tokuda; Byron Baron; Takao Kitagawa; Junko Akada; Shin-ichiro Maehara; Yoshihiko Maehara; Kazuyuki Nakamura

doi:10.1371/journal.pone.0109076

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Open Access

Peer-reviewed

Research Article

Gemcitabine Induces Poly (ADP-Ribose) Polymerase-1 (PARP-1) Degradation through Autophagy in Pancreatic Cancer

Yufeng Wang,

Affiliation Department of Biochemistry and Functional Proteomics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
⨯
Yasuhiro Kuramitsu ,

* E-mail: climates@yamaguchi-u.ac.jp

Affiliation Department of Biochemistry and Functional Proteomics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
⨯
Kazuhiro Tokuda,

Affiliation Department of Biochemistry and Functional Proteomics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
⨯
Byron Baron,

Affiliation Department of Biochemistry and Functional Proteomics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
⨯
Takao Kitagawa,

Affiliation Department of Biochemistry and Functional Proteomics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
⨯
Junko Akada,

Affiliation Department of Biochemistry and Functional Proteomics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
⨯
Shin-ichiro Maehara,

Affiliation Department of Surgery and Science, Graduate School of Medical Science, Kyusyu University, Fukuokashi, Fukuoka, Japan
⨯
Yoshihiko Maehara,

Affiliation Department of Surgery and Science, Graduate School of Medical Science, Kyusyu University, Fukuokashi, Fukuoka, Japan
⨯
Kazuyuki Nakamura

Affiliations Department of Biochemistry and Functional Proteomics, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan, Centre of Clinical Laboratories in Tokuyama Medical Association Hospital, Shunan, Japan
⨯

Gemcitabine Induces Poly (ADP-Ribose) Polymerase-1 (PARP-1) Degradation through Autophagy in Pancreatic Cancer

Yufeng Wang,
Yasuhiro Kuramitsu,
Kazuhiro Tokuda,
Byron Baron,
Takao Kitagawa,
Junko Akada,
Shin-ichiro Maehara,
Yoshihiko Maehara,
Kazuyuki Nakamura

Published: October 1, 2014
https://doi.org/10.1371/journal.pone.0109076

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