Enhanced Hepatogenic Transdifferentiation of Human Adipose Tissue Mesenchymal Stem Cells by Gene Engineering with Oct4 and Sox2

Sei-Myoung Han; Ye-Rin Coh; Jin-Ok Ahn; Goo Jang; Soo Young Yum; Sung-Keun Kang; Hee-Woo Lee; Hwa-Young Youn

doi:10.1371/journal.pone.0108874

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Peer-reviewed

Research Article

Enhanced Hepatogenic Transdifferentiation of Human Adipose Tissue Mesenchymal Stem Cells by Gene Engineering with Oct4 and Sox2

Sei-Myoung Han,

Affiliation Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, 151–742, Republic of Korea
⨯
Ye-Rin Coh,

Affiliation Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, 151–742, Republic of Korea
⨯
Jin-Ok Ahn,

Affiliation Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, 151–742, Republic of Korea
⨯
Goo Jang,

Affiliation Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Seoul National University, Seoul, 151–742, Republic of Korea
⨯
Soo Young Yum,

Affiliation Department of Theriogenology and Biotechnology, College of Veterinary Medicine, Seoul National University, Seoul, 151–742, Republic of Korea
⨯
Sung-Keun Kang,

Affiliation Stem Cell Research Center, K-STEMCELL Co. Ltd., Seoul, 153–768, Republic of Korea
⨯
Hee-Woo Lee ,

* E-mail: hyyoun@snu.ac.kr (HYY); lhwdinks90@gmail.com (HWL)

Affiliation Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, 151–742, Republic of Korea
⨯
Hwa-Young Youn

* E-mail: hyyoun@snu.ac.kr (HYY); lhwdinks90@gmail.com (HWL)

Affiliations Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, 151–742, Republic of Korea, Research Institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, Seoul, 151–742, Republic of Korea
⨯

Enhanced Hepatogenic Transdifferentiation of Human Adipose Tissue Mesenchymal Stem Cells by Gene Engineering with Oct4 and Sox2

Sei-Myoung Han,
Ye-Rin Coh,
Jin-Ok Ahn,
Goo Jang,
Soo Young Yum,
Sung-Keun Kang,
Hee-Woo Lee,
Hwa-Young Youn

Published: March 27, 2015
https://doi.org/10.1371/journal.pone.0108874

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Cell differentiation
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Hepatocytes
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Mesenchymal stem cells
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Urea
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Stem cell therapy
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Transfection
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Gene expression
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Liver transplantation
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