Effects of Isoxazolo-Pyridinone 7e, a Potent Activator of the Nurr1 Signaling Pathway, on Experimental Autoimmune Encephalomyelitis in Mice

Francesca Montarolo; Chiara Raffaele; Simona Perga; Serena Martire; Annamaria Finardi; Roberto Furlan; Samuel Hintermann; Antonio Bertolotto

doi:10.1371/journal.pone.0108791

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Peer-reviewed

Research Article

Effects of Isoxazolo-Pyridinone 7e, a Potent Activator of the Nurr1 Signaling Pathway, on Experimental Autoimmune Encephalomyelitis in Mice

Francesca Montarolo ,

* E-mail: francesca.montarolo@unito.it

Affiliation Neurobiology Unit, Neurologia 2 – CRESM (Regional Referring Center of Multiple Sclerosis), Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin and AOU San Luigi, Orbassano, Torino, Italy
⨯
Chiara Raffaele,

Affiliation Division of Neuroscience, Experimental Neurology Institute (INSPE), San Raffaele Scientific Institute, Milan, Italy
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Simona Perga,

Affiliation Neurobiology Unit, Neurologia 2 – CRESM (Regional Referring Center of Multiple Sclerosis), Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin and AOU San Luigi, Orbassano, Torino, Italy
⨯
Serena Martire,

Affiliation Neurobiology Unit, Neurologia 2 – CRESM (Regional Referring Center of Multiple Sclerosis), Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin and AOU San Luigi, Orbassano, Torino, Italy
⨯
Annamaria Finardi,

Affiliation Division of Neuroscience, Experimental Neurology Institute (INSPE), San Raffaele Scientific Institute, Milan, Italy
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Roberto Furlan,

Affiliation Division of Neuroscience, Experimental Neurology Institute (INSPE), San Raffaele Scientific Institute, Milan, Italy
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Samuel Hintermann,

Affiliation Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Basel, Switzerland
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Antonio Bertolotto

Affiliation Neurobiology Unit, Neurologia 2 – CRESM (Regional Referring Center of Multiple Sclerosis), Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin and AOU San Luigi, Orbassano, Torino, Italy
⨯

Effects of Isoxazolo-Pyridinone 7e, a Potent Activator of the Nurr1 Signaling Pathway, on Experimental Autoimmune Encephalomyelitis in Mice

Francesca Montarolo,
Chiara Raffaele,
Simona Perga,
Serena Martire,
Annamaria Finardi,
Roberto Furlan,
Samuel Hintermann,
Antonio Bertolotto

Published: September 29, 2014
https://doi.org/10.1371/journal.pone.0108791

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