Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial Reveals an Association of Nonspecific Interferon-γ Secretion with Increased HIV-1 Infection Risk: A Cohort-Based Modeling Study

Yunda Huang; Ann Duerr; Nicole Frahm; Lily Zhang; Zoe Moodie; Steve De Rosa; M. Juliana McElrath; Peter B. Gilbert

doi:10.1371/journal.pone.0108631

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Open Access

Peer-reviewed

Research Article

Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial Reveals an Association of Nonspecific Interferon-γ Secretion with Increased HIV-1 Infection Risk: A Cohort-Based Modeling Study

Yunda Huang ,

* E-mail: yunda@scharp.org

Affiliations Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Public Health Science Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Ann Duerr,

Affiliations Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Public Health Science Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Global Health, University of Washington, Seattle, Washington, United States of America, Department of Epidemiology, University of Washington, Seattle, Washington, United States of America
⨯
Nicole Frahm,

Affiliations Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Global Health, University of Washington, Seattle, Washington, United States of America
⨯
Lily Zhang,

Affiliation Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Zoe Moodie,

Affiliations Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Public Health Science Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Steve De Rosa,

Affiliations Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Laboratory Medicine, University of Washington, Seattle, Washington, United States of America
⨯
M. Juliana McElrath,

Affiliations Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Global Health, University of Washington, Seattle, Washington, United States of America, Department of Laboratory Medicine, University of Washington, Seattle, Washington, United States of America, Department of Medicine, University of Washington, Seattle, Washington, United States of America
⨯
Peter B. Gilbert

Affiliations Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Public Health Science Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Department of Biostatistics, University of Washington, Seattle, Washington, United States of America
⨯

Immune-Correlates Analysis of an HIV-1 Vaccine Efficacy Trial Reveals an Association of Nonspecific Interferon-γ Secretion with Increased HIV-1 Infection Risk: A Cohort-Based Modeling Study

Yunda Huang,
Ann Duerr,
Nicole Frahm,
Lily Zhang,
Zoe Moodie,
Steve De Rosa,
M. Juliana McElrath,
Peter B. Gilbert

Published: November 4, 2014
https://doi.org/10.1371/journal.pone.0108631

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