GTP Cyclohydrolase I Gene Polymorphisms Are Associated with Endothelial Dysfunction and Oxidative Stress in Patients with Type 2 Diabetes Mellitus

Pawel P. Wolkow; Wladyslaw Kosiniak-Kamysz; Grzegorz Osmenda; Grzegorz Wilk; Beata Bujak-Gizycka; Adam Ignacak; Mihir Kanitkar; Malgorzata Walus-Miarka; David G. Harrison; Ryszard Korbut; Maciej T. Malecki; Tomasz J. Guzik

doi:10.1371/journal.pone.0108587

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Peer-reviewed

Research Article

GTP Cyclohydrolase I Gene Polymorphisms Are Associated with Endothelial Dysfunction and Oxidative Stress in Patients with Type 2 Diabetes Mellitus

Pawel P. Wolkow,

Affiliations Centre for Medical Genomics OMICRON, Jagiellonian University Medical College, Krakow, Poland, Department of Pharmacology, Jagiellonian University Medical College, Krakow, Poland
⨯
Wladyslaw Kosiniak-Kamysz,

Affiliation Department of Internal and Agricultural Medicine, Jagiellonian University Medical College, Krakow, Poland
⨯
Grzegorz Osmenda,

Affiliation Department of Internal and Agricultural Medicine, Jagiellonian University Medical College, Krakow, Poland
⨯
Grzegorz Wilk,

Affiliation Department of Internal and Agricultural Medicine, Jagiellonian University Medical College, Krakow, Poland
⨯
Beata Bujak-Gizycka,

Affiliations Centre for Medical Genomics OMICRON, Jagiellonian University Medical College, Krakow, Poland, Department of Pharmacology, Jagiellonian University Medical College, Krakow, Poland
⨯
Adam Ignacak,

Affiliation Department of Internal and Agricultural Medicine, Jagiellonian University Medical College, Krakow, Poland
⨯
Mihir Kanitkar,

Affiliation Department of Clinical Pharmacology, Vanderbilt University, Nashville, TN, United States of America
⨯
Malgorzata Walus-Miarka,

Affiliation Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland
⨯
David G. Harrison,

Affiliation Department of Clinical Pharmacology, Vanderbilt University, Nashville, TN, United States of America
⨯
Ryszard Korbut,

Affiliation Department of Pharmacology, Jagiellonian University Medical College, Krakow, Poland
⨯
Maciej T. Malecki,

Affiliations Department of Metabolic Diseases, Jagiellonian University Medical College, Krakow, Poland, University Hospital, Krakow, Poland
⨯
Tomasz J. Guzik

* E-mail: t.guzik@uj.edu.pl

Affiliations Department of Internal and Agricultural Medicine, Jagiellonian University Medical College, Krakow, Poland, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom
⨯

GTP Cyclohydrolase I Gene Polymorphisms Are Associated with Endothelial Dysfunction and Oxidative Stress in Patients with Type 2 Diabetes Mellitus

Pawel P. Wolkow,
Wladyslaw Kosiniak-Kamysz,
Grzegorz Osmenda,
Grzegorz Wilk,
Beata Bujak-Gizycka,
Adam Ignacak,
Mihir Kanitkar,
Malgorzata Walus-Miarka,
David G. Harrison,
Ryszard Korbut

Published: November 4, 2014
https://doi.org/10.1371/journal.pone.0108587

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Haplotypes
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Diabetes mellitus
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Atherosclerosis
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Oxidative stress
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Genetic polymorphism
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Human genetics
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Type 2 diabetes
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Variant genotypes
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