An Integrated Model of Transcription Factor Diffusion Shows the Importance of Intersegmental Transfer and Quaternary Protein Structure for Target Site Finding

Open Access

Peer-reviewed

Research Article

Hugo G. Schmidt ,

* E-mail: hugo.schmidt@st-hughs.oxon.org (HS); karen.lipkow@babraham.ac.uk (KL)

Affiliation Department of Biochemistry & Cambridge Systems Biology Centre, University of Cambridge, Cambridge, United Kingdom
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Sven Sewitz,

Affiliations Department of Biochemistry & Cambridge Systems Biology Centre, University of Cambridge, Cambridge, United Kingdom, Nuclear Dynamics Programme, The Babraham Institute, Cambridge, United Kingdom
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Steven S. Andrews,

Affiliation Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
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Karen Lipkow

* E-mail: hugo.schmidt@st-hughs.oxon.org (HS); karen.lipkow@babraham.ac.uk (KL)

Affiliations Department of Biochemistry & Cambridge Systems Biology Centre, University of Cambridge, Cambridge, United Kingdom, Nuclear Dynamics Programme, The Babraham Institute, Cambridge, United Kingdom
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Transcription factors
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DNA-binding proteins
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Biochemical simulations
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Antennas
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DNA transcription
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Protein structure
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Chromatin
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DNA
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