Disturbed Flow Enhances Inflammatory Signaling and Atherogenesis by Increasing Thioredoxin-1 Level in Endothelial Cell Nuclei

Young-Mi Go; Dong Ju Son; Heonyong Park; Michael Orr; Li Hao; Wakako Takabe; Sandeep Kumar; Dong Won Kang; Chan Woo Kim; Hanjoong Jo; Dean P. Jones

doi:10.1371/journal.pone.0108346

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Open Access

Peer-reviewed

Research Article

Disturbed Flow Enhances Inflammatory Signaling and Atherogenesis by Increasing Thioredoxin-1 Level in Endothelial Cell Nuclei

Young-Mi Go ,

* E-mail: ygo@emory.edu (YMG); dpjones@emory.edu (DPJ)

Affiliation Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, Georgia, United States of America
⨯
Dong Ju Son,

Affiliation Division of Cardiology, Department of Medicine, Emory University, Atlanta, Georgia, United States of America
⨯
Heonyong Park,

Affiliation Department of Molecular Biology, Dankook University, Yongin-si, South Korea
⨯
Michael Orr,

Affiliation Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, Georgia, United States of America
⨯
Li Hao,

Affiliation Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, Georgia, United States of America
⨯
Wakako Takabe,

Affiliation Division of Cardiology, Department of Medicine, Emory University, Atlanta, Georgia, United States of America
⨯
Sandeep Kumar,

Affiliation Division of Cardiology, Department of Medicine, Emory University, Atlanta, Georgia, United States of America
⨯
Dong Won Kang,

Affiliation Division of Cardiology, Department of Medicine, Emory University, Atlanta, Georgia, United States of America
⨯
Chan Woo Kim,

Affiliation Division of Cardiology, Department of Medicine, Emory University, Atlanta, Georgia, United States of America
⨯
Hanjoong Jo,

Affiliations Division of Cardiology, Department of Medicine, Emory University, Atlanta, Georgia, United States of America, Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, United States of America
⨯
Dean P. Jones

* E-mail: ygo@emory.edu (YMG); dpjones@emory.edu (DPJ)

Affiliation Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Emory University, Atlanta, Georgia, United States of America
⨯

Disturbed Flow Enhances Inflammatory Signaling and Atherogenesis by Increasing Thioredoxin-1 Level in Endothelial Cell Nuclei

Young-Mi Go,
Dong Ju Son,
Heonyong Park,
Michael Orr,
Li Hao,
Wakako Takabe,
Sandeep Kumar,
Dong Won Kang,
Chan Woo Kim,
Hanjoong Jo

Published: September 29, 2014
https://doi.org/10.1371/journal.pone.0108346

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