Cardiac-Specific Inhibition of Kinase Activity in Calcium/Calmodulin-Dependent Protein Kinase Kinase-β Leads to Accelerated Left Ventricular Remodeling and Heart Failure after Transverse Aortic Constriction in Mice

Shin Watanabe; Takahiro Horie; Kazuya Nagao; Yasuhide Kuwabara; Osamu Baba; Hitoo Nishi; Naoya Sowa; Michiko Narazaki; Tetsuya Matsuda; Genzou Takemura; Hiromichi Wada; Koji Hasegawa; Takeshi Kimura; Koh Ono

doi:10.1371/journal.pone.0108201

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Peer-reviewed

Research Article

Cardiac-Specific Inhibition of Kinase Activity in Calcium/Calmodulin-Dependent Protein Kinase Kinase-β Leads to Accelerated Left Ventricular Remodeling and Heart Failure after Transverse Aortic Constriction in Mice

Shin Watanabe,

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⨯
Takahiro Horie,

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⨯
Kazuya Nagao,

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⨯
Yasuhide Kuwabara,

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⨯
Osamu Baba,

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⨯
Hitoo Nishi,

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⨯
Naoya Sowa,

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⨯
Michiko Narazaki,

Affiliation Department of Systems Science, Graduate School of Informatics, Kyoto University, Kyoto, Japan
⨯
Tetsuya Matsuda,

Affiliation Department of Systems Science, Graduate School of Informatics, Kyoto University, Kyoto, Japan
⨯
Genzou Takemura,

Affiliation Department of Internal Medicine, Asahi University, Gifu, Japan
⨯
Hiromichi Wada,

Affiliation Division of Translational Research, Kyoto Medical Center, National Hospital Organization, Kyoto, Japan
⨯
Koji Hasegawa,

Affiliation Division of Translational Research, Kyoto Medical Center, National Hospital Organization, Kyoto, Japan
⨯
Takeshi Kimura,

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⨯
Koh Ono

* E-mail: kohono@kuhp.kyoto-u.ac.jp

Affiliation Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
⨯

Cardiac-Specific Inhibition of Kinase Activity in Calcium/Calmodulin-Dependent Protein Kinase Kinase-β Leads to Accelerated Left Ventricular Remodeling and Heart Failure after Transverse Aortic Constriction in Mice

Shin Watanabe,
Takahiro Horie,
Kazuya Nagao,
Yasuhide Kuwabara,
Osamu Baba,
Hitoo Nishi,
Naoya Sowa,
Michiko Narazaki,
Tetsuya Matsuda,
Genzou Takemura

Published: September 25, 2014
https://doi.org/10.1371/journal.pone.0108201

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