3′-Deoxy-3′-[18F]-Fluorothymidine PET Imaging Reflects PI3K-mTOR-Mediated Pro-Survival Response to Targeted Therapy in Colorectal Cancer

Eliot T. McKinley; Ping Zhao; Robert J. Coffey; M. Kay Washington; H. Charles Manning

doi:10.1371/journal.pone.0108193

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Peer-reviewed

Research Article

3′-Deoxy-3′-[¹⁸F]-Fluorothymidine PET Imaging Reflects PI3K-mTOR-Mediated Pro-Survival Response to Targeted Therapy in Colorectal Cancer

Eliot T. McKinley,

Affiliations The Vanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University Medical School, Nashville, TN, United States of America, Department of Biomedical Engineering, Vanderbilt University Medical School, Nashville, TN, United States of America, Department of Medicine, Vanderbilt University Medical School, Nashville, TN, United States of America
⨯
Ping Zhao,

Affiliation The Vanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University Medical School, Nashville, TN, United States of America
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Robert J. Coffey,

Affiliations Department of Medicine, Vanderbilt University Medical School, Nashville, TN, United States of America, Department of Vanderbilt Ingram Cancer Center, Vanderbilt University Medical School, Nashville, TN, United States of America
⨯
M. Kay Washington,

Affiliations Department of Medicine, Vanderbilt University Medical School, Nashville, TN, United States of America, Department of Vanderbilt Ingram Cancer Center, Vanderbilt University Medical School, Nashville, TN, United States of America, Department of Pathology, Vanderbilt University Medical School, Nashville, TN, United States of America
⨯
H. Charles Manning

* E-mail: henry.c.manning@vanderbilt.edu

Affiliations The Vanderbilt University Institute of Imaging Science (VUIIS), Vanderbilt University Medical School, Nashville, TN, United States of America, Department of Biomedical Engineering, Vanderbilt University Medical School, Nashville, TN, United States of America, Department of Vanderbilt Ingram Cancer Center, Vanderbilt University Medical School, Nashville, TN, United States of America, Department of Radiology and Radiological Sciences, Vanderbilt University Medical School, Nashville, TN, United States of America, Department of Neurosurgery, Vanderbilt University Medical School, Nashville, TN, United States of America, Department of Chemical and Physical Biology, Vanderbilt University Medical School, Nashville, TN, United States of America
⨯

3′-Deoxy-3′-[¹⁸F]-Fluorothymidine PET Imaging Reflects PI3K-mTOR-Mediated Pro-Survival Response to Targeted Therapy in Colorectal Cancer

Eliot T. McKinley,
Ping Zhao,
Robert J. Coffey,
M. Kay Washington,
H. Charles Manning

Published: September 23, 2014
https://doi.org/10.1371/journal.pone.0108193

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