Overexpression of Extracellular Superoxide Dismutase Protects against Brain Injury Induced by Chronic Hypoxia

Nahla Zaghloul; Hardik Patel; Champa Codipilly; Philippe Marambaud; Stephen Dewey; Stephen Frattini; Patricio T. Huerta; Mansoor Nasim; Edmund J. Miller; Mohamed Ahmed

doi:10.1371/journal.pone.0108168

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Open Access

Peer-reviewed

Research Article

Overexpression of Extracellular Superoxide Dismutase Protects against Brain Injury Induced by Chronic Hypoxia

Nahla Zaghloul,

Affiliation Division of Neonatal-Perinatal Medicine, The Ohio State University and Nationwide Children's Hospital, Columbus, Ohio, United States of America
⨯
Hardik Patel,

Affiliation Division of Neonatal-Perinatal Medicine, Cohen Children's Medical Center of New York and Lilling Family Research laboratory, Feinstein Institute for Medical Research, Manhasset, New York, United States of America
⨯
Champa Codipilly,

Affiliation Division of Neonatal-Perinatal Medicine, Cohen Children's Medical Center of New York and Lilling Family Research laboratory, Feinstein Institute for Medical Research, Manhasset, New York, United States of America
⨯
Philippe Marambaud,

Affiliation Laboratory of Memory Disorders, Feinstein Institute for Medical Research, Manhasset, New York, United States of America
⨯
Stephen Dewey,

Affiliation Neuroimaging Department, Feinstein Institute for Medical Research, Manhasset, New York, United States of America
⨯
Stephen Frattini,

Affiliation Laboratory of Immune & Neural Networks, Feinstein Institute for Medical Research, Manhasset, New York, United States of America
⨯
Patricio T. Huerta,

Affiliations Laboratory of Immune & Neural Networks, Feinstein Institute for Medical Research, Manhasset, New York, United States of America, Department of Molecular Medicine, Hofstra North Shore LIJ School of Medicine, New York, United States of America
⨯
Mansoor Nasim,

Affiliation Department of Pathology, NSL-IJ, Manhasset, New York, United States of America
⨯
Edmund J. Miller,

Affiliations Department of Molecular Medicine, Hofstra North Shore LIJ School of Medicine, New York, United States of America, Division of Neonatal-Perinatal Medicine, Cohen Children's Medical Center of New York and Lilling Family Research laboratory, Feinstein Institute for Medical Research, Manhasset, New York, United States of America
⨯
Mohamed Ahmed

* E-mail: mahmed2@nshs.edu

Affiliations Division of Neonatal-Perinatal Medicine, The Ohio State University and Nationwide Children's Hospital, Columbus, Ohio, United States of America, Division of Neonatal-Perinatal Medicine, Cohen Children's Medical Center of New York and Lilling Family Research laboratory, Feinstein Institute for Medical Research, Manhasset, New York, United States of America
⨯

Overexpression of Extracellular Superoxide Dismutase Protects against Brain Injury Induced by Chronic Hypoxia

Nahla Zaghloul,
Hardik Patel,
Champa Codipilly,
Philippe Marambaud,
Stephen Dewey,
Stephen Frattini,
Patricio T. Huerta,
Mansoor Nasim,
Edmund J. Miller,
Mohamed Ahmed

Published: September 30, 2014
https://doi.org/10.1371/journal.pone.0108168

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Hypoxia
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Medical hypoxia
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Hippocampus
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Brain damage
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Superoxides
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Nitric oxide
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Hyperexpression techniques
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Positron emission tomography
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